Literature DB >> 235759

Nerve growth factor induces volume increase and enhances tyrosine hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats.

R Levi-Montalcini, L Aloe, E Mugnaini, F Oesch, H Thoenen.   

Abstract

Concomitant daily treatment of newborn rats for a 2-week to 1-month period with 10 mug/g of body weight of nerve growth factor and 100 mug/g of body weight of 6-hydroxydopamine produces in the cell bodies of adrenergic neurons the characteristic effects of the growth factor but in the nerve terminals the characteristic effects of 6-hydroxydopamine. The dual opposite effects result in a striking volume increase of sympathetic ganglia which far exceeds that produced by nerve growth factor alone. The selective induction of tyrosine hydroxylase [L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] in these chemically axotomized adrenergic neurons is even more pronounced than that produced by nerve growth factor alone in intact neurons.

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Year:  1975        PMID： 235759      PMCID： PMC432360          DOI： 10.1073/pnas.72.2.595

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

1.  GROWTH CONTROL OF NERVE CELLS BY A PROTEIN FACTOR AND ITS ANTISERUM: DISCOVERY OF THIS FACTOR MAY PROVIDE NEW LEADS TO UNDERSTANDING OF SOME NEUROGENETIC PROCESSES.

Authors:  R LEVI-MONTALCINI
Journal:  Science       Date:  1964-01-10       Impact factor: 47.728

2.  EFFECT OF DENERVATION AND ENZYME INHIBITION ON DOPA DECARBOXYLASE AND MONOAMINE OXIDASE ACTIVITIES OF RAT PINEAL GLAND.

Authors:  C OWMAN
Journal:  J Neurochem       Date:  1965-05       Impact factor: 5.372

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

Review 4.  The pharmacology of 6-hydroxydopamine.

Authors:  H Thoenen; J P Tranzer
Journal:  Annu Rev Pharmacol       Date:  1973       Impact factor: 13.820

Review 5.  Biochemistry of catecholamines.

Authors:  P B Molinoff; J Axelrod
Journal:  Annu Rev Biochem       Date:  1971       Impact factor: 23.643

6.  An electron microscopic study of the early changes proximal to a constriction in sympathetic nerves.

Authors:  K Kapeller; D Mayor
Journal:  Proc R Soc Lond B Biol Sci       Date:  1969-03-11

7.  Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine.

Authors:  H Thoenen; J P Tranzer
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1968

8.  Relationship between the rate of axoplasmic transport and subcellular distribution of enzymes involved in the synthesis of norepinephrine.

Authors:  F Oesch; U Otten; H Thoenen
Journal:  J Neurochem       Date:  1973-06       Impact factor: 5.372

9.  The nerve growth factor: purification as a 30,000-molecular-weight protein.

Authors:  V Bocchini; P U Angeletti
Journal:  Proc Natl Acad Sci U S A       Date:  1969-10       Impact factor: 11.205

10.  Fixation by means of glutaraldehyde-hydrogen peroxide reaction products.

Authors:  C Peracchia; B S Mittler
Journal:  J Cell Biol       Date:  1972-04       Impact factor: 10.539
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  17 in total

1.  The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea-pig.

Authors:  A Njå; D Purves
Journal:  J Physiol       Date:  1978-04       Impact factor: 5.182

2.  The locus ceruleus responds to signaling molecules obtained from the CSF by transfer through tanycytes.

Authors:  Cheng-Yuan Feng; Larisa M Wiggins; Christopher S von Bartheld
Journal:  J Neurosci       Date:  2011-06-22       Impact factor: 6.167

3.  Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra.

Authors:  M J Marti; C J James; T F Oo; W J Kelly; R E Burke
Journal:  J Neurosci       Date:  1997-03-15       Impact factor: 6.167

Review 4.  The nerve growth factor thirty-five years later.

Authors:  R Levi-Montalcini
Journal:  In Vitro Cell Dev Biol       Date:  1987-04

5.  Nerve growth factor-induced transformation of immature chromaffin cells in vivo into sympathetic neurons: effect of antiserum to nerve growth factor.

Authors:  L Aloe; R Levi-Montalcini
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

6.  Developing dorsal root ganglion neurons require trophic support from their central processes: evidence for a role of retrogradely transported nerve growth factor from the central nervous system to the periphery.

Authors:  H K Yip; E M Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

7.  Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell line.

Authors:  R Goodman; H R Herschman
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

8.  Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors.

Authors:  L Calza; L Giardino; A Giuliani; L Aloe; R Levi-Montalcini
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

9.  Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicity.

Authors:  W F Goins; K A Lee; J D Cavalcoli; M E O'Malley; S T DeKosky; D J Fink; J C Glorioso
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

10.  Identification of cDNA clones coding for rat tyrosine hydroxylase antigen.

Authors:  A Lamouroux; N Faucon Biguet; D Samolyk; A Privat; J C Salomon; J F Pujol; J Mallet
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205
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