Literature DB >> 2357585

Antigenic expression of cathepsin B in aged human brain.

H G Bernstein1, H Kirschke, B Wiederanders, D Schmidt, A Rinne.   

Abstract

The lysosomal thiol proteinase, cathepsin B, has been localized in different regions of aged human brain by use of the peroxidase-antiperoxidase technique. Cathepsin B-immunoreactive material was detected in multiple neurons of human hippocampus, neocortical area A 10, prefrontal gyrus and nuc. basalis of Meynert as well as in single white matter astrocytes. In brains of Alzheimer disease-affected subjects cathepsin B was revealed in neuritic plaques too. Possible functional consequences with regard to normal aging, neuropeptide metabolism and pathological changes are discussed.

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Year:  1990        PMID： 2357585     DOI： 10.1016/0361-9230(90)90157-u

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  13 in total

1.  The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.

Authors:  Gregory Hook; Vivian Hook; Mark Kindy
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

Review 2.  The role of beta-amyloid in the development of Alzheimer's disease.

Authors:  K Ii
Journal:  Drugs Aging       Date:  1995-08       Impact factor: 3.923

3.  Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged.

Authors:  K Ii; H Ito; E Kominami; A Hirano
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

Review 4.  Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.

Authors:  Gregory Hook; Thomas Reinheckel; Junjun Ni; Zhou Wu; Mark Kindy; Christoph Peters; Vivian Hook
Journal:  Pharmacol Rev       Date:  2022-07       Impact factor: 18.923

Review 5.  Microglia: Friend and foe in tauopathy.

Authors:  Kristian F Odfalk; Kevin F Bieniek; Sarah C Hopp
Journal:  Prog Neurobiol       Date:  2022-06-14       Impact factor: 10.885

6.  The possible role of lysosomal enzymes in the pathogenesis of hypertensive cerebral lesions in spontaneously hypertensive rats.

Authors:  C H Chue; N Yukioka; E Yamada; F Hazama
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

Review 7.  Cysteine cathepsins in neurological disorders.

Authors:  Anja Pišlar; Janko Kos
Journal:  Mol Neurobiol       Date:  2013-11-15       Impact factor: 5.590

8.  White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues.

Authors:  T Yamada; Y Yoshiyama; H Sato; M Seiki; A Shinagawa; M Takahashi
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

9.  Complexes of amyloid-beta and cystatin C in the human central nervous system.

Authors:  Weiqian Mi; Sonia S Jung; Haung Yu; Stephen D Schmidt; Ralph A Nixon; Paul M Mathews; Fabrizio Tagliavini; Efrat Levy
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

Review 10.  Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.

Authors:  Gregory Hook; J Steven Jacobsen; Kenneth Grabstein; Mark Kindy; Vivian Hook
Journal:  Front Neurol       Date:  2015-09-02       Impact factor: 4.003
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