| Literature DB >> 235747 |
J R Klinenberg, I Kippen, R Bluestone.
Abstract
The three general types of renal pathology associated with hyperuricemia are reviewed. Factors influencing urate solubility are discussed, as well as the effect of uricosuric drugs on renal urate handling, with particular emphasis upon their efficacy in competing with urate for protein binding sites. In addition, a new experimental model of hyperuricemic nephropathy is described which could yield valuable data concerning the complex relationships between hyperuricemia, urate deposition and renal function.Entities:
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Year: 1975 PMID： 235747 DOI： 10.1159/000180438
Source DB: PubMed Journal: Nephron ISSN： 1660-8151 Impact factor: 2.847