Literature DB >> 23573330

Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma.

Qingfu Zhang1, Jian Ming, Siyang Zhang, Bo Li, Xue Han, Xueshan Qiu.   

Abstract

Cytokeratin (pan) and epithelial membrane antigen (EMA) were considered as commonly useful epithelial markers to distinguish cancer from lymphoma, but the expression of cytokeratin (pan) and EMA had also been seen in some lymphomas. Here, we presented an unusual case of anaplastic large cell lymphoma (ALCL) absence of some lymphoid markers (Including CD3, CD20, Pax-5, CD45Ro) and positive for cytokeratin (pan) and EMA, which was misdiagnosed as metastatic carcinoma. Our case suggested that the epithelial markers (including cytokeratin and EMA) show an overlap with that of ALCL, which represented a diagnostic pitfall for confusing ALCL with metastatic carcinoma.

Entities:  

Keywords:  Anaplastic large cell lymphoma; anaplastic lymphoma kinase; immunohistochemistry

Mesh：

Substances：

Year:  2013        PMID： 23573330      PMCID： PMC3606873     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  7 in total

1.  Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challenge.

Authors:  Abbas Agaimy; Hanspeter Kirsche; Sabine Semrau; Heinrich Iro; Arndt Hartmann
Journal:  Hum Pathol       Date:  2012-03-09       Impact factor: 3.466

Review 2.  The molecular biology of pediatric lymphomas.

Authors:  R E Goldsby; W L Carroll
Journal:  J Pediatr Hematol Oncol       Date:  1998 Jul-Aug       Impact factor: 1.289

3.  Cytokeratin-positive large-cell lymphomas of B-cell lineage. A study of five phenotypically unusual cases verified by polymerase chain reaction.

Authors:  J Lasota; E Hyjek; C H Koo; J Blonski; M Miettinen
Journal:  Am J Surg Pathol       Date:  1996-03       Impact factor: 6.394

4.  Plasmacytoma with aberrant expression of myeloid markers, T-cell markers, and cytokeratin.

Authors:  J S Shin; G A Stopyra; M J Warhol; H A Multhaupt
Journal:  J Histochem Cytochem       Date:  2001-06       Impact factor: 2.479

5.  Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas.

Authors:  C Gustmann; M Altmannsberger; M Osborn; H Griesser; A C Feller
Journal:  Am J Pathol       Date:  1991-06       Impact factor: 4.307

6.  Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules.

Authors:  H D Foss; I Anagnostopoulos; I Araujo; C Assaf; G Demel; J A Kummer; M Hummel; H Stein
Journal:  Blood       Date:  1996-11-15       Impact factor: 22.113

7.  Cytokeratin positive T cell malignant lymphoma.

Authors:  W G McCluggage; M el-Agnaff; M D O'Hara
Journal:  J Clin Pathol       Date:  1998-05       Impact factor: 3.411
  7 in total
  2 in total

1.  [Blast-like tumor tissue in cervical lymph node with expression of placental alkaline phosphatase].

Authors:  C Fellbaum; S Kircher; U Oehler; R Blessing; A Rosenwald
Journal:  Pathologe       Date:  2017-03       Impact factor: 1.011

2.  Relapsed anaplastic lymphoma kinase-positive large B-cell lymphoma expressed cluster of differentiation 4 and cytokeratin: An initially misdiagnosed case corrected by immunoglobulin κ locus gene rearrangement detection.

Authors:  Yunfei Shi; Xianghong Li; Yuqin Song; Lixin Zhou; Qin Feng; Ping Wang; Chen Zhang; Weiping Liu; Yanhua Bai; Yumei Lai
Journal:  Oncol Lett       Date:  2017-05-17       Impact factor: 2.967
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.