Literature DB >> 2357228

Bifunctional effects of transforming growth factor-beta on migration of cultured rat aortic smooth muscle cells.

N Koyama1, T Koshikawa, N Morisaki, Y Saito, S Yoshida.   

Abstract

Migration of smooth muscle cells (SMC) in the arterial wall is important in the pathogenesis of atherosclerosis and is presumably regulated in both normal and atherosclerotic tissues. In this study, the effect of transforming growth factor-beta (TGF-beta) on the migration of rat aortic SMC was examined. TGF-beta alone enhanced the migration of SMC at concentrations of 10 to 50 pg/ml and its maximal effect was similar to that of platelet-derived growth factor (PDGF). Checker board analysis showed that TGF-beta had a chemotactic, but not a chemokinetic effect. PDGF also enhanced the migration in a dose-dependent manner and TGF-beta inhibited the PDGF-induced migration dose-dependently at 1.0 pg/ml to 1.0 ng/ml. These data suggest that TGF-beta is a bifunctional regulator of the migration of aortic SMC.

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Year:  1990        PMID： 2357228     DOI： 10.1016/0006-291x(90)90391-y

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

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2.  Estradiol attenuates directed migration of vascular smooth muscle cells in vitro.

Authors:  F D Kolodgie; A Jacob; P S Wilson; G C Carlson; A Farb; A Verma; R Virmani
Journal:  Am J Pathol       Date:  1996-03       Impact factor: 4.307

3.  Evidence for a role of collagen synthesis in arterial smooth muscle cell migration.

Authors:  E F Rocnik; B M Chan; J G Pickering
Journal:  J Clin Invest       Date:  1998-05-01       Impact factor: 14.808

4.  Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide.

Authors:  J E Cartwright; D P Holden; G S Whitley
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

5.  Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants.

Authors:  Girija Natarajan; Seetha Shankaran; Scott A McDonald; Abhik Das; Richard A Ehrenkranz; Ronald N Goldberg; Barbara J Stoll; Jon E Tyson; Rosemary D Higgins; Diana Schendel; David M Hougaard; Kristin Skogstrand; Poul Thorsen; Waldemar A Carlo
Journal:  Pediatr Cardiol       Date:  2012-06-10       Impact factor: 1.655

6.  Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration.

Authors:  S Biro; Y M Fu; Z X Yu; S E Epstein
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

7.  Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

Authors:  R Flaumenhaft; M Abe; Y Sato; K Miyazono; J Harpel; C H Heldin; D B Rifkin
Journal:  J Cell Biol       Date:  1993-02       Impact factor: 10.539

8.  A Tubing-Free Microfluidic Wound Healing Assay Enabling the Quantification of Vascular Smooth Muscle Cell Migration.

Authors:  Yuanchen Wei; Feng Chen; Tao Zhang; Deyong Chen; Xin Jia; Junbo Wang; Wei Guo; Jian Chen
Journal:  Sci Rep       Date:  2015-09-14       Impact factor: 4.379
  8 in total

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