Literature DB >> 2357225

Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines.

E Sugiyama1, K Uemura, A Hara, T Taketomi.   

Abstract

The cell numbers of three mouse neuroblastoma cell lines were decreased upon incubation with lysosphingolipids in the following order of effectiveness: lysosulfatide (lysoCS) greater than psychosine (Ps) greater than sphingosylphosphocholine (SPC). The different cell lines showed characteristic sensitivities to various concentrations of lysolipids less than 150 microM. Interestingly, only SPC induced neurite outgrowth and changed the lipid composition, modifying the amounts of cholesterol, sphingomyelin (SM) and ganglioside GM3 in all cell lines. The effect of SPC on these cell lines was comparable to the effect of N-acetyl SPC (NAcSPC) rather than that of SM.

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Year:  1990        PMID： 2357225     DOI： 10.1016/0006-291x(90)90383-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells.

Authors:  S T Engberg; T Aoyama; S E Alexson; T Hashimoto; L T Svensson
Journal:  Biochem J       Date:  1997-04-15       Impact factor: 3.857

Review 2.  Sphingolipid metabolites: members of a new class of lipid second messengers.

Authors:  S Spiegel; S Milstien
Journal:  J Membr Biol       Date:  1995-08       Impact factor: 1.843

Review 3.  Pathology and current treatment of neurodegenerative sphingolipidoses.

Authors:  Matthias Eckhardt
Journal:  Neuromolecular Med       Date:  2010-08-22       Impact factor: 3.843

4.  Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.

Authors:  A Berger; D Rosenthal; S Spiegel
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

5.  Lysosulfatide regulates the motility of a neural precursor cell line via calcium-mediated process collapse.

Authors:  M Hans; A Pusch; L Dai; K Racké; D Swandulla; V Gieselmann; J Kappler
Journal:  Neurochem Res       Date:  2008-08-22       Impact factor: 3.996

Review 6.  Sphingosylphosphorylcholine in cancer progress.

Authors:  Hong-Wei Yue; Qing-Chuan Jing; Ping-Ping Liu; Jing Liu; Wen-Jing Li; Jing Zhao
Journal:  Int J Clin Exp Med       Date:  2015-08-15

7.  In vivo anti-tumour effect of 3'-sulphonoquinovosyl 1'-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine.

Authors:  H Sahara; M Ishikawa; N Takahashi; S Ohtani; N Sato; S Gasa; T Akino; K Kikuchi
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

8.  Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity.

Authors:  Christopher J Folts; Nicole Scott-Hewitt; Christoph Pröschel; Margot Mayer-Pröschel; Mark Noble
Journal:  PLoS Biol       Date:  2016-12-15       Impact factor: 8.029

9.  Anti-tumor effect of chemically synthesized sulfolipids based on sea urchin's natural sulfonoquinovosylmonoacylglycerols.

Authors:  Hiroeki Sahara; Shinya Hanashima; Takayuki Yamazaki; Shunya Takahashi; Fumio Sugawara; Seiji Ohtani; Masako Ishikawa; Yoshiyuki Mizushina; Keisuke Ohta; Kumiko Shimozawa; Shinsei Gasa; Kouichi Jimbow; Kengo Sakaguchi; Noriyuki Sato; Nobuaki Takahashi
Journal:  Jpn J Cancer Res       Date:  2002-01

10.  Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.

Authors:  N N Desai; R O Carlson; M E Mattie; A Olivera; N E Buckley; T Seki; G Brooker; S Spiegel
Journal:  J Cell Biol       Date:  1993-06       Impact factor: 10.539
  10 in total

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