Literature DB >> 2357211

Structure of human monocyte chemotactic protein gene and its regulation by TPA.

Y J Shyy1, Y S Li, P E Kolattukudy.   

Abstract

Monocyte chemotactic protein released by endothelium plays an important role in inflammation, immune reactions and probably in atherogenesis. To elucidate the regulation of synthesis of this protein, the human gene encoding its synthesis was cloned and its nucleotide sequence was determined. This gene is composed of 3 exons of 145, 118 and 478 bp in length with 2 introns of 800 and 385 bp in length. Phorbol ester responsive elements (TRE) were found 129 and 157 bp upstream from the translation initiation site and the phorbol ester treatment of endothelial cell cultures elevated the transcript level of this gene.

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Year:  1990        PMID： 2357211     DOI： 10.1016/0006-291x(90)90338-n

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  27 in total

Review 1.  Mechanisms of the blood-brain barrier disruption in HIV-1 infection.

Authors:  Michal Toborek; Yong Woo Lee; Govinder Flora; Hong Pu; Ibolya E András; Edward Wylegala; Bernhard Hennig; Avindra Nath
Journal:  Cell Mol Neurobiol       Date:  2005-02       Impact factor: 5.046

2.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-07-25       Impact factor: 16.971

3.  The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites.

Authors:  S P Lim; A Garzino-Demo
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

4.  The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

Authors:  J Y Shyy; M C Lin; J Han; Y Lu; M Petrime; S Chien
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

5.  Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium.

Authors:  Y J Shyy; H J Hsieh; S Usami; S Chien
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

6.  Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines.

Authors:  F Marra; A J Valente; M Pinzani; H E Abboud
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

7.  Human monocyte colony-stimulating factor stimulates the gene expression of monocyte chemotactic protein-1 and increases the adhesion of monocytes to endothelial monolayers.

Authors:  Y J Shyy; L L Wickham; J P Hagan; H J Hsieh; Y L Hu; S H Telian; A J Valente; K L Sung; S Chien
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

8.  Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin.

Authors:  F Colotta; F L Sciacca; M Sironi; W Luini; M J Rabiet; A Mantovani
Journal:  Am J Pathol       Date:  1994-05       Impact factor: 4.307

9.  Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase.

Authors:  J A Satriano; M Shuldiner; K Hora; Y Xing; Z Shan; D Schlondorff
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808

10.  Functional role of the cis-acting elements in human monocyte chemotactic protein-1 gene in the regulation of its expression by phorbol ester in human glioblastoma cells.

Authors:  Y S Li; P E Kolattukudy
Journal:  Mol Cell Biochem       Date:  1994-12-21       Impact factor: 3.396
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