BACKGROUND: In the common form of Alzheimer's disease (AD), neurofibrillary tangles, which are associated with cognitive dysfunction, initially develop in the anterior subhippocampal (perirhinal/entorhinal) cortex before reaching the hippocampus. This area plays a key role in visual recognition memory (VRM). Impaired VRM could therefore be an early marker of AD. METHODS: An extensive neuropsychological assessment including VRM tasks was performed in 26 patients with single-domain amnestic mild cognitive impairment at baseline. We evaluated the diagnostic accuracy of neuropsychological tests using ROC curve analyses in a prospective longitudinal study until conversion to probable AD or with a follow-up of at least 6 years. RESULTS: VRM performance predicted conversion to AD with a sensitivity of 80% and a specificity of 90.9%. Combining the assessment of VRM with a verbal memory task increased diagnostic accuracy. CONCLUSIONS: Cognitive 'biomarkers' evaluating the function of brain areas that are the target of degenerative change should be considered for the early diagnosis of AD.
BACKGROUND: In the common form of Alzheimer's disease (AD), neurofibrillary tangles, which are associated with cognitive dysfunction, initially develop in the anterior subhippocampal (perirhinal/entorhinal) cortex before reaching the hippocampus. This area plays a key role in visual recognition memory (VRM). Impaired VRM could therefore be an early marker of AD. METHODS: An extensive neuropsychological assessment including VRM tasks was performed in 26 patients with single-domain amnestic mild cognitive impairment at baseline. We evaluated the diagnostic accuracy of neuropsychological tests using ROC curve analyses in a prospective longitudinal study until conversion to probable AD or with a follow-up of at least 6 years. RESULTS: VRM performance predicted conversion to AD with a sensitivity of 80% and a specificity of 90.9%. Combining the assessment of VRM with a verbal memory task increased diagnostic accuracy. CONCLUSIONS: Cognitive 'biomarkers' evaluating the function of brain areas that are the target of degenerative change should be considered for the early diagnosis of AD.
Authors: Javier Oltra-Cucarella; Miriam Sánchez-SanSegundo; Darren M Lipnicki; John D Crawford; Richard B Lipton; Mindy J Katz; Andrea R Zammit; Nikolaos Scarmeas; Efthimios Dardiotis; Mary H Kosmidis; Antonio Guaita; Roberta Vaccaro; Ki Woong Kim; Ji Won Han; Nicole A Kochan; Henry Brodaty; José A Pérez-Vicente; Luis Cabello-Rodríguez; Perminder S Sachdev; Rosario Ferrer-Cascales Journal: Int Psychogeriatr Date: 2018-10-25 Impact factor: 3.878
Authors: Christine Bastin; Mohamed Ali Bahri; Frédéric Miévis; Christian Lemaire; Fabienne Collette; Sarah Genon; Jessica Simon; Bénédicte Guillaume; Rachel A Diana; Andrew P Yonelinas; Eric Salmon Journal: Neuropsychologia Date: 2014-08-27 Impact factor: 3.139
Authors: Javier Oltra-Cucarella; Miriam Sánchez-SanSegundo; Darren M Lipnicki; Perminder S Sachdev; John D Crawford; José A Pérez-Vicente; Luis Cabello-Rodríguez; Rosario Ferrer-Cascales Journal: J Am Geriatr Soc Date: 2018-05-10 Impact factor: 5.562
Authors: N Philippi; V Noblet; E Duron; B Cretin; C Boully; I Wisniewski; M L Seux; C Martin-Hunyadi; E Chaussade; C Demuynck; S Kremer; S Lehéricy; D Gounot; J P Armspach; O Hanon; F Blanc Journal: Alzheimers Res Ther Date: 2016-07-30 Impact factor: 6.982