Literature DB >> 23571454

Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization.

Jinqiang Zhang1, Johan Kemmink, Dirk T S Rijkers, Rob M J Liskamp.   

Abstract

Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of vancomycin, followed by measurement of its binding affinity for small peptide ligands using ITC.

Entities:  

Mesh:

Substances:

Year:  2013        PMID: 23571454     DOI: 10.1039/c3cc40628h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics.

Authors:  Edward Marschall; Max J Cryle; Julien Tailhades
Journal:  J Biol Chem       Date:  2019-10-31       Impact factor: 5.157

2.  Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles.

Authors:  Christopher D Smith; Michael F Greaney
Journal:  Org Lett       Date:  2013-09-03       Impact factor: 6.005

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.