RATIONALE AND OBJECTIVES: Cardiac computer tomography (CT) image-based vertebral bone mineral density (BMD) assessment and the influence of cardiovascular disease risk factors on BMD have not been systematically evaluated, especially in a community-based, multiethnic population. METHODS: A cross-sectional study design is used to determine if cardiac CT image is a reliable source to assess vertebral BMD, and a total of 2028 CT images were obtained from the Multi-Ethnic Study of Atherosclerosis, a large, diverse US cohort of adults 45 to 84 years of age. RESULTS: Cardiac CT image allows the rapid assessment of vertebral BMD and related fractures. The mean BMD was significantly higher in men compared with women for thoracic vertebrae (143.2 ± 41.2 vs 138.7 ± 42.7 mg/cm³, respectively, P = .014), as well as for lumbar vertebrae (125.0 ± 37.9 vs 117.2 ± 39.4 mg/cm³, respectively, P < .0001). Thoracic and lumbar BMDs are closely correlated (correlation coefficient 0.87, P < .001), independent of age and other confounders including sex and race. African American men had the highest thoracic BMD among all race/ethnicity and sex subgroups. Prevalence of fractures in total vertebrae is 4.2%. Lumbar had approximately 2 times higher prevalence of fracture than thoracic, and the prevalence of vertebral fractures is 1.5% and 3.1% for thoracic and lumbar vertebrae, respectively. CONCLUSIONS: Using cardiac CT images to garner and assess vertebral BMD is a feasible and reliable method. Cardiac CT has the additional advantages of evaluate vertebral bone health while assessing cardiovascular disease risk with no extra cost or radiation exposure.
RATIONALE AND OBJECTIVES: Cardiac computer tomography (CT) image-based vertebral bone mineral density (BMD) assessment and the influence of cardiovascular disease risk factors on BMD have not been systematically evaluated, especially in a community-based, multiethnic population. METHODS: A cross-sectional study design is used to determine if cardiac CT image is a reliable source to assess vertebral BMD, and a total of 2028 CT images were obtained from the Multi-Ethnic Study of Atherosclerosis, a large, diverse US cohort of adults 45 to 84 years of age. RESULTS: Cardiac CT image allows the rapid assessment of vertebral BMD and related fractures. The mean BMD was significantly higher in men compared with women for thoracic vertebrae (143.2 ± 41.2 vs 138.7 ± 42.7 mg/cm³, respectively, P = .014), as well as for lumbar vertebrae (125.0 ± 37.9 vs 117.2 ± 39.4 mg/cm³, respectively, P < .0001). Thoracic and lumbar BMDs are closely correlated (correlation coefficient 0.87, P < .001), independent of age and other confounders including sex and race. African American men had the highest thoracic BMD among all race/ethnicity and sex subgroups. Prevalence of fractures in total vertebrae is 4.2%. Lumbar had approximately 2 times higher prevalence of fracture than thoracic, and the prevalence of vertebral fractures is 1.5% and 3.1% for thoracic and lumbar vertebrae, respectively. CONCLUSIONS: Using cardiac CT images to garner and assess vertebral BMD is a feasible and reliable method. Cardiac CT has the additional advantages of evaluate vertebral bone health while assessing cardiovascular disease risk with no extra cost or radiation exposure.
Authors: W Shen; J Chen; M Gantz; M Punyanitya; S B Heymsfield; D Gallagher; J Albu; E Engelson; D Kotler; X Pi-Sunyer; S Shapses Journal: Osteoporos Int Date: 2011-12-16 Impact factor: 4.507
Authors: B C C Khoo; K Brown; C Cann; K Zhu; S Henzell; V Low; S Gustafsson; R I Price; R L Prince Journal: Osteoporos Int Date: 2008-12-24 Impact factor: 4.507
Authors: Daniele Massera; Petra Buzkova; Anna E Bortnick; David S Owens; SongShou Mao; Dong Li; Ian H De Boer; Bryan R Kestenbaum; Matthew J Budoff; Jorge R Kizer Journal: Atherosclerosis Date: 2021-08-26 Impact factor: 5.162
Authors: Nisha Bansal; Ronit Katz; Ian H de Boer; Bryan Kestenbaum; David S Siscovick; Andrew N Hoofnagle; Russell Tracy; Gail A Laughlin; Michael H Criqui; Mathew J Budoff; Dong Li; Joachim H Ix Journal: J Clin Endocrinol Metab Date: 2013-10-03 Impact factor: 5.958