| Literature DB >> 23570791 |
Ying-Zi Xu1, Shendong Yuan, Simeon Bowers, Roy K Hom, Wayman Chan, Hing L Sham, Yong L Zhu, Paul Beroza, Hu Pan, Eric Brecht, Nanhua Yao, Julie Lougheed, Jiangli Yan, Danny Tam, Zhao Ren, Lany Ruslim, Michael P Bova, Dean R Artis.
Abstract
Utilizing a structure based design approach, combined with extensive medicinal chemistry execution, highly selective, potent and novel BACE1 inhibitor 8 (BACE1 Alpha assay IC50=8nM) was made from a weak μM potency hit in an extremely efficient way. The detailed SAR and general design approaches will be discussed.Entities:
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Year: 2013 PMID： 23570791 DOI： 10.1016/j.bmcl.2013.03.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823