| Literature DB >> 23570365 |
Tomohiro Igarashi1, Shigeru Arai, Atsushi Nishida.
Abstract
Anti carbocyanative cyclization using 1,6-enynes under nickel catalysis is described. This reaction is triggered by hydronickelation to alkenes followed by carbometalation. Steric repulsion caused by the bulky substituents on alkynes promotes isomerization of the carbon-carbon double bond geometry in an organonickel intermediate to introduce both alkyl and cyano groups in an anti fashion.Entities:
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Year: 2013 PMID： 23570365 DOI： 10.1021/jo400342y
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354