Literature DB >> 23570337

Hyrtimomines A-C, new heteroaromatic alkaloids from a sponge Hyrtios sp.

Rei Momose1, Naonobu Tanaka, Jane Fromont, Jun'ichi Kobayashi.   

Abstract

Three new alkaloids, hyrtimomines A-C (1-3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1-3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids possessing a fused hexacyclic 6/5/6/6/7/5 ring system, while hyrtimomine C (3) is an alkaloid consisting of hydroxyindole and azepino-hydroxyindole moieties. Hyrtimomine A (1) exhibited cytotoxicity against KB and L1210 cells.

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Year:  2013        PMID： 23570337     DOI： 10.1021/ol400687b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

Review 1.  Bioactive Natural Products of Marine Sponges from the Genus Hyrtios.

Authors:  Nourhan Hisham Shady; Ebaa M El-Hossary; Mostafa A Fouad; Tobias A M Gulder; Mohamed Salah Kamel; Usama Ramadan Abdelmohsen
Journal:  Molecules       Date:  2017-05-11       Impact factor: 4.411

2.  Expedient Synthesis of Indolo[2,3-b]quinolines, Chromeno[2,3-b]indoles, and 3-Alkenyl-oxindoles from 3,3'-Diindolylmethanes and Evaluation of Their Antibiotic Activity against Methicillin-Resistant Staphylococcus aureus.

Authors:  Chandrasekhar Challa; Jaice Ravindran; Mohini Mohan Konai; Sunil Varughese; Jubi Jacob; B S Dileep Kumar; Jayanta Haldar; Ravi S Lankalapalli
Journal:  ACS Omega       Date:  2017-08-30

3.  A Natural Quinazoline Derivative from Marine Sponge Hyrtios erectus Induces Apoptosis of Breast Cancer Cells via ROS Production and Intrinsic or Extrinsic Apoptosis Pathways.

Authors:  Arun Kumar De; Ramachandran Muthiyan; Samiran Mondal; Nilkamal Mahanta; Debasis Bhattacharya; Perumal Ponraj; Kangayan Muniswamy; Anandamoy Kundu; Madhu Sudhan Kundu; Jai Sunder; Dhanasekar Karunakaran; Asit Kumar Bera; Sibnarayan Dam Roy; Dhruba Malakar
Journal:  Mar Drugs       Date:  2019-11-23       Impact factor: 5.118

Review 4.  Marine Indole Alkaloids.

Authors:  Natalie Netz; Till Opatz
Journal:  Mar Drugs       Date:  2015-08-06       Impact factor: 5.118

5.  Anticancer activity of marine sponge Hyrtios sp. extract in human colorectal carcinoma RKO cells with different p53 status.

Authors:  Hyun Kyung Lim; Woori Bae; Hyi-Seung Lee; Joohee Jung
Journal:  Biomed Res Int       Date:  2014-08-27       Impact factor: 3.411

6.  In Silico Evaluation of Antifungal Compounds from Marine Sponges against COVID-19-Associated Mucormycosis.

Authors:  Omkar Pokharkar; Hariharan Lakshmanan; Grigory Zyryanov; Mikhail Tsurkan
Journal:  Mar Drugs       Date:  2022-03-20       Impact factor: 5.118
  6 in total

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