O A Osonuga1, A Osonuga, A A Osonuga, I O Osonuga. 1. Department of Pharmacology and Physiology, University of Cape Coast, Cape Coast, Ghana ; School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
Abstract
OBJECTIVE: To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether. METHODS: Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities. They were divided into two groups; 'Q' and 'A', receiving quinine and artemether, respectively. Jaundice was assessed by clinical examination. RESULTS: Sixteen out of 32 children recruited (representing 50%) presented with jaundice on the day of recruitment. The mean age was (7.00°C2.56) years. On day 3, four patients in 'A' and six patients in 'Q' had jaundice. By day 7, no child had jaundice. CONCLUSION: The study has shown that both drugs resolve jaundice although artemether relatively resolves it faster by the third day.
OBJECTIVE: To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether. METHODS: Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities. They were divided into two groups; 'Q' and 'A', receiving quinine and artemether, respectively. Jaundice was assessed by clinical examination. RESULTS: Sixteen out of 32 children recruited (representing 50%) presented with jaundice on the day of recruitment. The mean age was (7.00°C2.56) years. On day 3, four patients in 'A' and six patients in 'Q' had jaundice. By day 7, no child had jaundice. CONCLUSION: The study has shown that both drugs resolve jaundice although artemether relatively resolves it faster by the third day.
Entities:
Keywords:
Artemether; Jaundice; Quinine; Severe malaria; South-west Nigeria
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