OBJECTIVE: To review the evidence base for different treatment strategies in intraparenchymal neurocysticercosis in adults and children. METHOD: A literature search of Medline, EMBASE, LILACS, and the Cochrane Database from 1980 to 2008, updated in 2012, resulted in the identification of 10 Class I or Class II trials of cysticidal drugs administered with or without corticosteroids in the treatment of neurocysticercosis. RESULTS: The available data demonstrate that albendazole therapy, administered with or without corticosteroids, is probably effective in decreasing both long-term seizure frequency and the number of cysts demonstrable radiologically in adults and children with neurocysticercosis, and is well-tolerated. There is insufficient information to assess the efficacy of praziquantel. RECOMMENDATIONS: Albendazole plus either dexamethasone or prednisolone should be considered for adults and children with neurocysticercosis, both to decrease the number of active lesions on brain imaging studies (Level B) and to reduce long-term seizure frequency (Level B). The evidence is insufficient to support or refute the use of steroid treatment alone in patients with intraparenchymal neurocysticercosis (Level U).
OBJECTIVE: To review the evidence base for different treatment strategies in intraparenchymal neurocysticercosis in adults and children. METHOD: A literature search of Medline, EMBASE, LILACS, and the Cochrane Database from 1980 to 2008, updated in 2012, resulted in the identification of 10 Class I or Class II trials of cysticidal drugs administered with or without corticosteroids in the treatment of neurocysticercosis. RESULTS: The available data demonstrate that albendazole therapy, administered with or without corticosteroids, is probably effective in decreasing both long-term seizure frequency and the number of cysts demonstrable radiologically in adults and children with neurocysticercosis, and is well-tolerated. There is insufficient information to assess the efficacy of praziquantel. RECOMMENDATIONS: Albendazole plus either dexamethasone or prednisolone should be considered for adults and children with neurocysticercosis, both to decrease the number of active lesions on brain imaging studies (Level B) and to reduce long-term seizure frequency (Level B). The evidence is insufficient to support or refute the use of steroid treatment alone in patients with intraparenchymal neurocysticercosis (Level U).
Authors: Héctor H Garcia; E Javier Pretell; Robert H Gilman; S Manuel Martinez; Lawrence H Moulton; Oscar H Del Brutto; Genaro Herrera; Carlton A W Evans; Armando E Gonzalez Journal: N Engl J Med Date: 2004-01-15 Impact factor: 91.245
Authors: Christina M Coyle; Siddhartha Mahanty; Joseph R Zunt; Mitchell T Wallin; Paul T Cantey; A Clinton White; Seth E O'Neal; Jose A Serpa; Paul M Southern; Patricia Wilkins; Anne E McCarthy; Elizabeth S Higgs; Theodore E Nash Journal: PLoS Negl Trop Dis Date: 2012-05-29
Authors: Luis Jean Pierre Meneses Quiroz; Isidro Gonzales; Edwin Javier Pretell; Herbert Saavedra; Hector H Garcia Journal: Neurol Clin Pract Date: 2015-12
Authors: Kriti Thapa; Matthew L Romo; Arturo Carpio; Denise Leslie; Howard Andrews; W Allen Hauser; Elizabeth A Kelvin Journal: Trans R Soc Trop Med Hyg Date: 2018-02-01 Impact factor: 2.184