Literature DB >> 23568675

Iterative curettage is associated with local control in giant cell tumors involving the distal tibia.

Saleh A AlSulaimani1, Robert E Turcotte.   

Abstract

BACKGROUND: The distal tibia is an unusual location for a giant cell tumor (GCT). Treatment choices are unclear because of their rarity, the anatomy of the ankle, and difficulties associated with reconstruction. QUESTIONS/PURPOSES: We assessed: (1) the treatment modalities used by participating Canadian bone tumor centers for distal tibia GCTs; (2) the incidence of local recurrence and their management; and (3) patients' function after treatment.
METHODS: A prospective tumor database served to identify all 31 patients with primarily treated distal tibia GCTs between 1991 and 2010. We extracted patients and tumor characteristics, treatment modalities for initial and recurrent tumors, and the Musculoskeletal Tumor Society (MSTS) and Toronto Extremity Salvage (TESS) scores. The median followup was 58 months (range, 24-192 months).
RESULTS: Extended curettage was the only modality of treatment for all patients including all subsequent local recurrences. Nine had local recurrence, three of which had a second local recurrence; one had a third recurrence. Ultimately all patients were in remission at last followup. The local recurrence rate was 29% and appeared higher compared with recent series of all anatomic sites. The mean final MSTS and TESS scores were 91% (range, 71%-100%) and 88% (range, 35%-100%), respectively.
CONCLUSIONS: Extended curettage was the unique modality of surgical treatment for all tumors. We found the incidence of local recurrence higher than that reported for other locations but recurrences were manageable with repeated curettage. Complications and function appeared better than those reported for series of ankle fusion or reconstruction for bone tumors.

Entities:  

Mesh:

Year:  2013        PMID: 23568675      PMCID: PMC3705059          DOI: 10.1007/s11999-013-2965-z

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN: 0009-921X            Impact factor:   4.176


  55 in total

1.  Thermal effects of acrylic cementation at bone tumour sites.

Authors:  D A Nelson; M E Barker; B H Hamlin
Journal:  Int J Hyperthermia       Date:  1997 May-Jun       Impact factor: 3.914

2.  Results of giant cell tumor of bone treated with intralesional excision.

Authors:  Paul Saiz; Walter Virkus; Patricia Piasecki; Alexander Templeton; Susan Shott; Steven Gitelis
Journal:  Clin Orthop Relat Res       Date:  2004-07       Impact factor: 4.176

3.  Subchondral replacement: a comparative analysis of reconstruction with methyl methacrylate or autogenous bone graft.

Authors:  F J Frassica; F H Sim; D J Pritchard; E Y Chao
Journal:  Chir Organi Mov       Date:  1990

4.  Reconstruction after wide resection of the entire distal fibula in malignant bone tumours.

Authors:  Ralf Dieckmann; Helmut Ahrens; Arne Streitbürger; Tymoteusz Borys Budny; Marcel-Philipp Henrichs; Volker Vieth; Carsten Gebert; Jendrik Hardes
Journal:  Int Orthop       Date:  2009-12-29       Impact factor: 3.075

5.  Giant cell tumor of bone.

Authors:  K M Yip; P C Leung; S M Kumta
Journal:  Clin Orthop Relat Res       Date:  1996-02       Impact factor: 4.176

6.  Limb salvage in distal tibial osteosarcoma using a custom mega prosthesis.

Authors:  M V Natarajan; K Annamalai; S Williams; R Selvaraj; T S Rajagopal
Journal:  Int Orthop       Date:  2000       Impact factor: 3.075

7.  Giant-cell tumor of bone. An analysis of two hundred and eighteen cases.

Authors:  R R Goldenberg; C J Campbell; M Bonfiglio
Journal:  J Bone Joint Surg Am       Date:  1970-06       Impact factor: 5.284

8.  Sarcomatous degeneration of giant cell tumours.

Authors:  S Boriani; A Sudanese; N Baldini; P Picci
Journal:  Ital J Orthop Traumatol       Date:  1986-06

9.  Hydrogen peroxide inhibits giant cell tumor and osteoblast metabolism in vitro.

Authors:  N C Nicholson; W K Ramp; J S Kneisl; K K Kaysinger
Journal:  Clin Orthop Relat Res       Date:  1998-02       Impact factor: 4.176

10.  Giant-cell tumor of bone.

Authors:  M Campanacci; N Baldini; S Boriani; A Sudanese
Journal:  J Bone Joint Surg Am       Date:  1987-01       Impact factor: 5.284

View more
  4 in total

1.  Intratibial injection of patient-derived tumor cells from giant cell tumor of bone elicits osteolytic reaction in nude mouse.

Authors:  Leqin Xu; Zhipeng Wu; Zhenhua Zhou; Xinghai Yang; Jianru Xiao
Journal:  Oncol Lett       Date:  2018-07-16       Impact factor: 2.967

Review 2.  Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.

Authors:  Robert Koucheki; Aaron Gazendam; Jonathan Perera; Anthony Griffin; Peter Ferguson; Jay Wunder; Kim Tsoi
Journal:  Eur J Orthop Surg Traumatol       Date:  2022-03-30

3.  Successful Treatment of a Massive Desmoplastic Fibroma of the Ilium without Surgery: A Case Report with Long-Term Follow-Up.

Authors:  Hideyuki Kinoshita; Takeshi Ishii; Hiroto Kamoda; Yoko Hagiwara; Toshinori Tsukanishi; Sumihisa Orita; Kazuhide Inage; Naoya Hirosawa; Seiji Ohtori; Tsukasa Yonemoto
Journal:  Case Rep Orthop       Date:  2020-03-20

4.  Extended curettage and heat ablation for desmoplastic fibroma of the distal femur with a 12-year follow-up period: A case report.

Authors:  Masahiro Yokouchi; Yoshinori Ueno; Satoshi Nagano; Hirofumi Shimada; Shunsuke Nakamura; Takao Setoguchi; Ichiro Kawamura; Yasuhiro Ishidou; Setsuro Komiya
Journal:  Oncol Lett       Date:  2014-06-12       Impact factor: 2.967

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.