OBJECTIVE: To evaluate the significance of incidentally discovered breast lesions on 18-fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT. METHODS: 6050 (18)F-FDG PET/CT studies, performed between January 2009 and February 2012, were retrospectively reviewed. 55 lesions in 50 patients were identified. Additional work-up, including mammography, ultrasound, follow-up (18)F-FDG PET/CT and biopsy, was available for 39 incidental breast lesions in 36 patients. All patients were female, with mean age 61.5 years (range 36-90 years). The maximum standardised uptake value (SUVmax), CT size and CT Breast Imaging Reporting and Data System (BI-RADS®) scores were compared between the malignant and the benign subgroups, using the unpaired t-test and Fisher's exact test. Tests were two-sided and a p-value of <0.05 was considered to be significant. RESULTS: Incidental breast lesions were identified in 50 (0.8%) of 6050 (18)F-FDG PET/CT studies. 21 (53.8%) of the 39 breast incidentalomas were malignant on biopsy or imaging, of which 15 (38.5%) represented a second primary breast cancer. A statistically significant difference in the mean SUVmax between malignant and benign breast lesions was observed (p=0.021). Malignancy was significantly more common in the CT BI-RADS Category 4 or greater groups (76.2%; p=0.0105). CONCLUSION: Incidental breast lesions detected at (18)F-FDG PET/CT are uncommon. When detected, however, they may represent malignancy in up to 53.8% of cases. ADVANCES IN KNOWLEDGE: SUVmax and CT findings at (18)F-FDG PET/CT can assist with differentiating benign and malignant breast conditions, guiding further evaluation with dedicated breast imaging. Review of (18)F-FDG PET/CT-detected breast lesions by a breast radiologist may be helpful in determining the need for and correlation with further breast imaging. Radiologists and nuclear medicine physicians should be cognisant of breast pathology when reporting (18)F-FDG PET/CT image data sets.
OBJECTIVE: To evaluate the significance of incidentally discovered breast lesions on 18-fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT. METHODS: 6050 (18)F-FDG PET/CT studies, performed between January 2009 and February 2012, were retrospectively reviewed. 55 lesions in 50 patients were identified. Additional work-up, including mammography, ultrasound, follow-up (18)F-FDG PET/CT and biopsy, was available for 39 incidental breast lesions in 36 patients. All patients were female, with mean age 61.5 years (range 36-90 years). The maximum standardised uptake value (SUVmax), CT size and CT Breast Imaging Reporting and Data System (BI-RADS®) scores were compared between the malignant and the benign subgroups, using the unpaired t-test and Fisher's exact test. Tests were two-sided and a p-value of <0.05 was considered to be significant. RESULTS: Incidental breast lesions were identified in 50 (0.8%) of 6050 (18)F-FDG PET/CT studies. 21 (53.8%) of the 39 breast incidentalomas were malignant on biopsy or imaging, of which 15 (38.5%) represented a second primary breast cancer. A statistically significant difference in the mean SUVmax between malignant and benign breast lesions was observed (p=0.021). Malignancy was significantly more common in the CT BI-RADS Category 4 or greater groups (76.2%; p=0.0105). CONCLUSION: Incidental breast lesions detected at (18)F-FDG PET/CT are uncommon. When detected, however, they may represent malignancy in up to 53.8% of cases. ADVANCES IN KNOWLEDGE: SUVmax and CT findings at (18)F-FDG PET/CT can assist with differentiating benign and malignant breast conditions, guiding further evaluation with dedicated breast imaging. Review of (18)F-FDG PET/CT-detected breast lesions by a breast radiologist may be helpful in determining the need for and correlation with further breast imaging. Radiologists and nuclear medicine physicians should be cognisant of breast pathology when reporting (18)F-FDG PET/CT image data sets.
Authors: N Avril; S Bense; S I Ziegler; J Dose; W Weber; C Laubenbacher; W Römer; F Jänicke; M Schwaiger Journal: J Nucl Med Date: 1997-08 Impact factor: 10.057
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Authors: Kyung Min Shin; Hye Jung Kim; Su Jin Jung; Hyo Soon Lim; Sang Woo Lee; Seung Hyun Cho; Yun-Jin Jang; Hui Joong Lee; Gab Chul Kim; Jin Hyang Jung; Ji Young Park Journal: J Breast Cancer Date: 2015-03-27 Impact factor: 3.588