A comparative study of the efficacy of postoperative analgesia with intraoperative epidural lidocaine with or without morphine.

We compared postoperative analgesia in 15 patients (group A) who were given intraoperative epidural morphine 3 mg and lidocaine 150 mg after laminectomy/discectomy with that of 15 patients (group B) who were given only epidural lidocaine 150 mg. Epidural administration was accomplished by direct placement of the epidural catheter into the epidural space under direct vision during surgery. Eight patients (53%) in group A and 15 patients (100%) in group B required supplementary narcotics during the first 24 h postoperatively (P<0.05). The amount of supplementary narcotics given to group A patients was significantly less than that for group B (P<0.05), and the pain scores for group A patients were also significantly lower at 1, 2, and 6 h postoperatively (P<0.05). There was no difference in the observed side effects in the two groups. We conclude that postoperative pain relief following laminectomy/discectomy is superior when epidural morphine is added to lidocaine than when lidocaine is being used alone.

RCT Entities:   Population Interventions Outcomes