| Literature DB >> 23568057 |
Alexander Papolos1, William H Frishman.
Abstract
The development of cardiac-specific adeno-associated viral vectors capable of long-term transgenic expression has opened new avenues in the therapeutic approach to heart failure. Failing cardiomyocytes demonstrate altered calcium-handling secondary to depressed expression and activity of myocardial sarcoendoplasmic reticulum calcium ATPase 2a (SERCA2a). This observation has led to a large body of research investigating the therapeutic utility of SERCA2a gene therapy in heart failure.Entities:
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Year: 2013 PMID： 23568057 DOI： 10.1097/CRD.0b013e3182749cdb
Source DB: PubMed Journal: Cardiol Rev ISSN： 1061-5377 Impact factor: 2.644