OBJECTIVE: To investigate the relationship between subjective memory complaints (SMC) and the stress hormone cortisol using diurnal measures in older, cognitively intact subjects. METHODS: This cross-sectional study conducted at a university research center included 64 volunteers (with or without SMC) with a mean age of 78.6 (±6.3) years and diagnosis of cognitively normal based on objective neuropsychological testing. Measures of diurnal salivary cortisol, depressive symptoms, episodic memory performance, level of anxiety, and apolipoprotein E (APOE) e4 allele status were obtained. RESULTS: In multivariate logistic regression analyses with SMC as outcome, averaged postpeak cortisol, the cortisol awakening response, and depressive symptoms were significant predictors, whereas gender, memory performance, anxiety, and APOE-e4 status were not. CONCLUSIONS: Significant associations between SMC and diurnal measures of cortisol in cognitively intact elderly suggest that hypothalamic-pituitary-adrenal axis dysfunction may contribute to early neuropathologic changes in older adults who complain of memory decline undetected on neuropsychological testing.
OBJECTIVE: To investigate the relationship between subjective memory complaints (SMC) and the stress hormone cortisol using diurnal measures in older, cognitively intact subjects. METHODS: This cross-sectional study conducted at a university research center included 64 volunteers (with or without SMC) with a mean age of 78.6 (±6.3) years and diagnosis of cognitively normal based on objective neuropsychological testing. Measures of diurnal salivary cortisol, depressive symptoms, episodic memory performance, level of anxiety, and apolipoprotein E (APOE) e4 allele status were obtained. RESULTS: In multivariate logistic regression analyses with SMC as outcome, averaged postpeak cortisol, the cortisol awakening response, and depressive symptoms were significant predictors, whereas gender, memory performance, anxiety, and APOE-e4 status were not. CONCLUSIONS: Significant associations between SMC and diurnal measures of cortisol in cognitively intact elderly suggest that hypothalamic-pituitary-adrenal axis dysfunction may contribute to early neuropathologic changes in older adults who complain of memory decline undetected on neuropsychological testing.
Authors: P D Evans; C Fredhoi; C Loveday; F Hucklebridge; E Aitchison; D Forte; A Clow Journal: Int J Psychophysiol Date: 2010-12-24 Impact factor: 2.997
Authors: Melissa J Slavin; Henry Brodaty; Nicole A Kochan; John D Crawford; Julian N Trollor; Brian Draper; Perminder S Sachdev Journal: Am J Geriatr Psychiatry Date: 2010-08 Impact factor: 4.105
Authors: Oliver T Wolf; Isabel Dziobek; Pauline McHugh; Victoria Sweat; Mony J de Leon; Elizabeth Javier; Antonio Convit Journal: Neurobiol Aging Date: 2005 Nov-Dec Impact factor: 4.673
Authors: Laura B Zahodne; Assawin Gongvatana; Ronald A Cohen; Brian R Ott; Geoffrey Tremont Journal: Am J Geriatr Psychiatry Date: 2013-04-28 Impact factor: 4.105
Authors: Rainbow T H Ho; Ted C T Fong; Joshua C Y Yau; Wai Chi Chan; Joseph S K Kwan; Patrick K C Chiu; Linda C W Lam Journal: Front Aging Neurosci Date: 2020-02-21 Impact factor: 5.750