Literature DB >> 2356698

Effects of long-term chloroquine exposure on the phospholipid metabolism in retina and pigment epithelium of the mouse.

A Hallberg1, P Naeser, A Andersson.   

Abstract

The influence of 6 month's treatment of normal mice with chloroquine on neuroretina and retinal pigment epithelium has been investigated biochemically and morphologically. All classes of neuroretinal phospholipids, except lysophosphatidylcholine, showed increased 14C-glucose incorporation after chloroquine treatment. No metabolic changes were observed in the pigment epithelium after the chloroquine treatment. Morphological signs of phospholipidosis were only evident in the ganglion cells of the neuroretina. It is concluded that long-term treatment with chloroquine does not affect pigment epithelium phospholipid metabolism but leads to morphological and biochemical signs of phospholipidosis in the neuroretina.

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Year:  1990        PMID： 2356698     DOI： 10.1111/j.1755-3768.1990.tb01892.x

Source DB:  PubMed          Journal:  Acta Ophthalmol (Copenh)        ISSN： 0001-639X


  11 in total

1.  Macular ganglion cell-inner plexiform layer thickness for detection of early retinal toxicity of hydroxychloroquine.

Authors:  Emrah Kan; Konuralp Yakar; Mehmet Derya Demirag; Mustafa Gok
Journal:  Int Ophthalmol       Date:  2017-07-10       Impact factor: 2.031

2.  Selective thinning of the perifoveal inner retina as an early sign of hydroxychloroquine retinal toxicity.

Authors:  S Pasadhika; G A Fishman; D Choi; M Shahidi
Journal:  Eye (Lond)       Date:  2010-04-16       Impact factor: 3.775

3.  Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine.

Authors:  Lucia Tanga; Marco Centofanti; Francesco Oddone; Mariacristina Parravano; Vincenzo Parisi; Lucia Ziccardi; Barbara Kroegler; Roberto Perricone; Gianluca Manni
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2011-01-21       Impact factor: 3.117

4.  Effect of phospholipidosis on the cellular pharmacokinetics of chloroquine.

Authors:  Nan Zheng; Xinyuan Zhang; Gus R Rosania
Journal:  J Pharmacol Exp Ther       Date:  2010-12-14       Impact factor: 4.030

5.  A possible early sign of hydroxychloroquine macular toxicity.

Authors:  Livia M Brandao; Anja M Palmowski-Wolfe
Journal:  Doc Ophthalmol       Date:  2016-01-20       Impact factor: 2.379

6.  Chloroquine-induced lipidosis in the rat retina: functional and morphological changes after withdrawal of the drug.

Authors:  G Duncker; T Bredehorn
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-06       Impact factor: 3.117

7.  Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the "flying saucer" sign).

Authors:  Eric Chen; David M Brown; Matthew S Benz; Richard H Fish; Tien P Wong; Rosa Y Kim; James C Major
Journal:  Clin Ophthalmol       Date:  2010-10-21

8.  Analysis of Clinical Factors Associated with Retinal Morphological Changes in Patients with Primary Sjögren's Syndrome.

Authors:  Jee Myung Yang; Mi Sun Sung; Yong Sok Ji; Hwan Heo; Sang Woo Park
Journal:  PLoS One       Date:  2016-06-21       Impact factor: 3.240

9.  Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine.

Authors:  Yigit Ulviye; Tugcu Betul; Tarakcioglu Hatice Nur; Celik Selda
Journal:  Indian J Ophthalmol       Date:  2013-04       Impact factor: 1.848

10.  Spectral-Domain Optical Coherence Tomography of Preclinical Chloroquine Maculopathy in Egyptian Rheumatoid Arthritis Patients.

Authors:  Riham S H M Allam; Mai N Abd-Elmohsen; Mohamed M Khafagy; Karim A Raafat; Sherif M Sheta
Journal:  J Ophthalmol       Date:  2015-08-02       Impact factor: 1.909
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