PURPOSE: The purpose of the study is to evaluate the incidence and hemodynamic consequences of right ventricular (RV) and left ventricular (LV) dysfunction in critically ill patients with H1N1 infection. PATIENTS AND METHODS: This is a retrospective analysis of all patients admitted to the intensive care unit of an academic hospital between October 2009 and March 2011 with severe H1N1 infection. Hemodynamic measurements and respiratory conditions were noted daily during the intensive care unit stay. RESULTS: Forty-six patients were admitted with severe H1N1 infection. Echocardiography was obtained in 39 patients on admission: 28 (72%) had abnormal ventricular function, of whom 13 (46%) had isolated LV abnormalities, 11 (39%) had isolated RV dysfunction, and 4 (14%) had biventricular dysfunction. Echocardiography was repeated in 19 of the 39 patients during their hospitalization: RV function tended to worsen with time, but LV function tended to normalize. The ventricular abnormalities were not associated with history, severity of the respiratory failure, or hemodynamic status. However, patients with ventricular dysfunction needed more aggressive therapy, including more frequent use of vasopressor and inotropic agents and of rescue ventilatory strategies, such as inhaled nitric oxide, prone positioning, and extracorporeal membrane oxygenation. CONCLUSIONS: These observations emphasize the high incidence of cardiac dysfunction in patients with H1N1 influenza infections.
PURPOSE: The purpose of the study is to evaluate the incidence and hemodynamic consequences of right ventricular (RV) and left ventricular (LV) dysfunction in critically illpatients with H1N1 infection. PATIENTS AND METHODS: This is a retrospective analysis of all patients admitted to the intensive care unit of an academic hospital between October 2009 and March 2011 with severe H1N1 infection. Hemodynamic measurements and respiratory conditions were noted daily during the intensive care unit stay. RESULTS: Forty-six patients were admitted with severe H1N1 infection. Echocardiography was obtained in 39 patients on admission: 28 (72%) had abnormal ventricular function, of whom 13 (46%) had isolated LV abnormalities, 11 (39%) had isolated RV dysfunction, and 4 (14%) had biventricular dysfunction. Echocardiography was repeated in 19 of the 39 patients during their hospitalization: RV function tended to worsen with time, but LV function tended to normalize. The ventricular abnormalities were not associated with history, severity of the respiratory failure, or hemodynamic status. However, patients with ventricular dysfunction needed more aggressive therapy, including more frequent use of vasopressor and inotropic agents and of rescue ventilatory strategies, such as inhaled nitric oxide, prone positioning, and extracorporeal membrane oxygenation. CONCLUSIONS: These observations emphasize the high incidence of cardiac dysfunction in patients with H1N1influenza infections.
Authors: Jennifer L Nguyen; Wan Yang; Kazuhiko Ito; Thomas D Matte; Jeffrey Shaman; Patrick L Kinney Journal: JAMA Cardiol Date: 2016-06-01 Impact factor: 14.676
Authors: Stephen J Huang; Marek Nalos; Louise Smith; Arvind Rajamani; Anthony S McLean Journal: Intensive Care Med Date: 2018-05-22 Impact factor: 17.440
Authors: Sonja Kytömaa; Sheila Hegde; Brian Claggett; Jacob A Udell; Wayne Rosamond; Jonathan Temte; Kristin Nichol; Jacqueline D Wright; Scott D Solomon; Orly Vardeny Journal: JAMA Cardiol Date: 2019-04-01 Impact factor: 14.676
Authors: Orly Vardeny; Jacob A Udell; Jacob Joseph; Michael E Farkouh; Adrian F Hernandez; Alison J McGeer; H Keipp Talbot; Deepak L Bhatt; Christopher P Cannon; Shaun G Goodman; Inder Anand; David L DeMets; Jon Temte; Janet Wittes; Kristin Nichol; Clyde W Yancy; J Michael Gaziano; Lawton S Cooper; KyungMann Kim; Scott D Solomon Journal: Am Heart J Date: 2018-05-23 Impact factor: 4.749