Literature DB >> 23566518

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel.

George P Lahm1, Daniel Cordova, James D Barry, Thomas F Pahutski, Ben K Smith, Jeffrey K Long, Eric A Benner, Caleb W Holyoke, Kathleen Joraski, Ming Xu, Mark E Schroeder, Ty Wagerle, Michael J Mahaffey, Rejane M Smith, My-Hahn Tong.   

Abstract

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID: 23566518     DOI: 10.1016/j.bmcl.2013.03.031

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  The intravenous and oral pharmacokinetics of lotilaner in dogs.

Authors:  Céline E Toutain; Wolfgang Seewald; Martin Jung
Journal:  Parasit Vectors       Date:  2017-11-01       Impact factor: 3.876

2.  The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls).

Authors:  Lucien Rufener; Vanessa Danelli; Daniel Bertrand; Heinz Sager
Journal:  Parasit Vectors       Date:  2017-11-01       Impact factor: 3.876

Review 3.  Rational approaches for the design of various GABA modulators and their clinical progression.

Authors:  Kavita Bhagat; Jatinder V Singh; Piyusha P Pagare; Nitish Kumar; Anchal Sharma; Gurinder Kaur; Nihar Kinarivala; Srinivasa Gandu; Harbinder Singh; Sahil Sharma; Preet Mohinder S Bedi
Journal:  Mol Divers       Date:  2020-03-13       Impact factor: 2.943

4.  Identification of transcriptome and fluralaner responsive genes in the common cutworm Spodoptera litura Fabricius, based on RNA-seq.

Authors:  Zhong-Qiang Jia; Di Liu; Ying-Chuan Peng; Zhao-Jun Han; Chun-Qing Zhao; Tao Tang
Journal:  BMC Genomics       Date:  2020-02-03       Impact factor: 3.969

  4 in total

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