Literature DB >> 23566517

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mark J Mitton-Fry1, Steven J Brickner, Judith C Hamel, Lori Brennan, Jeffrey M Casavant, Michael Chen, Tao Chen, Xiaoyuan Ding, James Driscoll, Joel Hardink, Thuy Hoang, Erbing Hua, Michael D Huband, Meghan Maloney, Anthony Marfat, Sandra P McCurdy, Dale McLeod, Michael Plotkin, Usa Reilly, Shaughn Robinson, John Schafer, Richard M Shepard, James F Smith, Gregory G Stone, Chakrapani Subramanyam, Kwansik Yoon, Wei Yuan, Richard P Zaniewski, Christopher Zook.   

Abstract

A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
Copyright © 2013. Published by Elsevier Ltd.

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Year:  2013        PMID： 23566517     DOI： 10.1016/j.bmcl.2013.03.047

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.

Authors:  Christopher M Tan; Charles J Gill; Jin Wu; Nathalie Toussaint; Jingjun Yin; Takayuki Tsuchiya; Charles G Garlisi; David Kaelin; Peter T Meinke; Lynn Miesel; David B Olsen; Armando Lagrutta; Hideyuki Fukuda; Ryuta Kishii; Masaya Takei; Kouhei Oohata; Tomoko Takeuchi; Taku Shibue; Hisashi Takano; Akinori Nishimura; Yasumichi Fukuda; Sheo B Singh
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

2.  Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.

Authors:  Asha S Nayar; Thomas J Dougherty; Folkert Reck; Jason Thresher; Ning Gao; Adam B Shapiro; David E Ehmann
Journal:  Antimicrob Agents Chemother       Date:  2014-10-27       Impact factor: 5.191

3.  High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.

Authors:  Mattia Zampieri; Balazs Szappanos; Maria Virginia Buchieri; Andrej Trauner; Ilaria Piazza; Paola Picotti; Sébastien Gagneux; Sonia Borrell; Brigitte Gicquel; Joel Lelievre; Balazs Papp; Uwe Sauer
Journal:  Sci Transl Med       Date:  2018-02-21       Impact factor: 17.956

4.  Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.

Authors:  Sheo B Singh; David E Kaelin; Jin Wu; Lynn Miesel; Christopher M Tan; Peter T Meinke; David Olsen; Armando Lagrutta; Prudence Bradley; Jun Lu; Sangita Patel; Keith W Rickert; Robert F Smith; Stephen Soisson; Changqing Wei; Hideyuki Fukuda; Ryuta Kishii; Masaya Takei; Yasumichi Fukuda
Journal:  ACS Med Chem Lett       Date:  2014-03-12       Impact factor: 4.345

5.  Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding.

Authors:  Shahul Hameed P; Praveena Manjrekar; Anandkumar Raichurkar; Vikas Shinde; Jayashree Puttur; Gajanan Shanbhag; Murugan Chinnapattu; Vikas Patil; Suresh Rudrapatana; Sreevalli Sharma; C N Naveen Kumar; Radha Nandishaiah; Prashanti Madhavapeddi; D Sriram; Suresh Solapure; Vasan K Sambandamurthy
Journal:  ACS Med Chem Lett       Date:  2015-05-22       Impact factor: 4.345

6.  1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.

Authors:  Yanran Lu; Chelsea A Mann; Sheri Nolan; Jessica A Collins; Elizabeth Parker; Jonathan Papa; Sandip Vibhute; Seyedehameneh Jahanbakhsh; Mary Thwaites; David Hufnagel; Manzour H Hazbón; Jane Moreno; Timothy T Stedman; Thomas Wittum; Daniel J Wozniak; Neil Osheroff; Jack C Yalowich; Mark J Mitton-Fry
Journal:  ACS Med Chem Lett       Date:  2022-05-09       Impact factor: 4.632

7.  Benzimidazoles: novel mycobacterial gyrase inhibitors from scaffold morphing.

Authors:  Shahul Hameed P; Anandkumar Raichurkar; Prashanti Madhavapeddi; Sreenivasaiah Menasinakai; Sreevalli Sharma; Parvinder Kaur; Radha Nandishaiah; Vijender Panduga; Jitendar Reddy; Vasan K Sambandamurthy; D Sriram
Journal:  ACS Med Chem Lett       Date:  2014-06-02       Impact factor: 4.345

8.  Identification of novel bacterial DNA gyrase inhibitors: An in silico study.

Authors:  Hamzeh Rahimi; Ali Najafi; Habib Eslami; Babak Negahdari; Mehrdad Moosazadeh Moghaddam
Journal:  Res Pharm Sci       Date:  2016 May-Jun

9.  Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure-Activity Relationship (HQSAR) Modeling of Amino-Imino Tautomers.

Authors:  Marcelle L F Bispo; Camilo H S Lima; Laura N F Cardoso; André L P Candéa; Flávio A F M Bezerra; Maria C S Lourenço; Maria G M O Henriques; Ricardo B Alencastro; Carlos R Kaiser; Marcus V N Souza; Magaly G Albuquerque
Journal:  Pharmaceuticals (Basel)       Date:  2017-06-09

10.  Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase.

Authors:  Katharina Jarolim; Giorgia Del Favero; Doris Ellmer; Timo D Stark; Thomas Hofmann; Michael Sulyok; Hans-Ulrich Humpf; Doris Marko
Journal:  Arch Toxicol       Date:  2016-09-28       Impact factor: 5.153
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