Literature DB >> 23566262

Purification and identification of an ACE inhibitory peptide from walnut protein.

Meng Liu, Ming Du, Yingchun Zhang, Weili Xu, Cong Wang, Kejian Wang, Lanwei Zhang.   

Abstract

In the present study, a novel angiotensin I-converting enzyme (ACE)-inhibitory peptide, P-2a2, was purified to homogeneity from walnut protein hydrolysate by ultrafiltration, consecutive column chromatography, and high-performance liquid chromatography. The purified peptide was characterized by matrix-assisted laser desorption ionization time-of-flight mass spectrophotometry and a liquid-phase peptide sequencer. The molecular mass of P-2a2 was tested to be 1033.42 D. Its amino acid sequence was determined to be Trp-Pro-Glu-Arg-Pro-Pro-Gln-Ile-Pro. The potent ACE-inhibitory peptide is an enneapeptide and shows a high ACE-inhibitory activity, with an IC50 value of 25.67 μg/mL.

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Year:  2013        PMID： 23566262     DOI： 10.1021/jf4001378

Source DB:  PubMed          Journal:  J Agric Food Chem        ISSN： 0021-8561            Impact factor:   5.279


  14 in total

1.  Effect of walnut protein hydrolysate on scopolamine-induced learning and memory deficits in mice.

Authors:  Wenzhi Li; Tiantian Zhao; Jianan Zhang; Jucai Xu; Dongxiao Sun-Waterhouse; Mouming Zhao; Guowan Su
Journal:  J Food Sci Technol       Date:  2017-07-05       Impact factor: 2.701

2.  Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet.

Authors:  Xiao-Yue Yang; Di-Ying Zhong; Guo-Liang Wang; Run-Guang Zhang; You-Lin Zhang
Journal:  Nutrients       Date:  2021-04-22       Impact factor: 5.717

Review 3.  STRUCTURAL CHARACTERISTICS AND ANTIHYPERTENSIVE EFFECTS OF ANGIOTENSIN-I-CONVERTING ENZYME INHIBITORY PEPTIDES IN THE RENIN-ANGIOTENSIN AND KALLIKREIN KININ SYSTEMS.

Authors:  Sivananthan Manoharan; Adawiyah Suriza Shuib; Noorlidah Abdullah
Journal:  Afr J Tradit Complement Altern Med       Date:  2017-01-13

Review 4.  Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants.

Authors:  Ceren Daskaya-Dikmen; Aysun Yucetepe; Funda Karbancioglu-Guler; Hayrettin Daskaya; Beraat Ozcelik
Journal:  Nutrients       Date:  2017-03-23       Impact factor: 5.717

5.  Separation and Characterization of Antioxidative and Angiotensin Converting Enzyme Inhibitory Peptide from Jellyfish Gonad Hydrolysate.

Authors:  Qin Zhang; Chengcheng Song; Jun Zhao; Xiaomei Shi; Meiling Sun; Jing Liu; Yinghuan Fu; Wengang Jin; Beiwei Zhu
Journal:  Molecules       Date:  2018-01-05       Impact factor: 4.411

6.  Angiotensin-converting enzyme inhibitor activity of peptides derived from Kacang goat skin collagen through thermolysin hydrolysis.

Authors:  Arby'in Pratiwi; Thoyib R Hakim; Mohammad Z Abidin; Nanung A Fitriyanto; Jamhari Jamhari; Rusman Rusman; Yuny Erwanto
Journal:  Vet World       Date:  2021-01-21

7.  Isolation of a novel bio-peptide from walnut residual protein inducing apoptosis and autophagy on cancer cells.

Authors:  Sihui Ma; Di Huang; Mengxin Zhai; Lubing Yang; Sen Peng; Changxu Chen; Xiaoru Feng; Qiang Weng; Bolin Zhang; Meiyu Xu
Journal:  BMC Complement Altern Med       Date:  2015-11-23       Impact factor: 3.659

8.  Identification of an ACE-Inhibitory Peptide from Walnut Protein and Its Evaluation of the Inhibitory Mechanism.

Authors:  Cong Wang; Maolin Tu; Di Wu; Hui Chen; Cheng Chen; Zhenyu Wang; Lianzhou Jiang
Journal:  Int J Mol Sci       Date:  2018-04-11       Impact factor: 5.923

Review 9.  Bioactive Peptides from Walnut Residue Protein.

Authors:  Xiangyang Li; Manli Guo; Jingtian Chi; Jiangang Ma
Journal:  Molecules       Date:  2020-03-12       Impact factor: 4.411

Review 10.  Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds.

Authors:  Soheila Abachi; Laurent Bazinet; Lucie Beaulieu
Journal:  Mar Drugs       Date:  2019-10-29       Impact factor: 5.118
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