Literature DB >> 23566000

Overexpression of multiple myeloma SET domain (MMSET) is associated with advanced tumor aggressiveness and poor prognosis in serous ovarian carcinoma.

Shanshan Yang1, Yunyan Zhang, Fanling Meng, Yunduo Liu, Bairong Xia, Min Xiao, Ye Xu, Xiaoming Ning, Huiming Li, Ge Lou.   

Abstract

Multiple myeloma SET domain (MMSET) has been shown to be overexpressed in many different cancer tissues. Our study was to investigate the expression of MMSET in serous ovarian carcinoma and to evaluate its clinical significance in patients with serous ovarian carcinoma. Immunohistochemistry was performed to determine the expression of MMSET in 132 serous ovarian carcinoma, 32 normal ovarian and fallopian tube specimens. The high expression of MMSET was observed in 49.2% (65/132) in patients with serous ovarian carcinoma. MMSET high expression correlated with the advanced extent of serous ovarian carcinoma and poor outcome. MMSET may serve as a new molecular marker to predict the prognosis of serous ovarian carcinoma in the clinic.

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Year:  2013        PMID： 23566000     DOI： 10.3109/1354750X.2013.773082

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  8 in total

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Journal:  J Biol Chem       Date:  2018-06-26       Impact factor: 5.157

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Review 3.  Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?

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4.  An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer.

Authors:  Zhen Yang; Allison Jones; Martin Widschwendter; Andrew E Teschendorff
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5.  Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.

Authors:  Relja Popovic; Eva Martinez-Garcia; Eugenia G Giannopoulou; Quanwei Zhang; Qingyang Zhang; Teresa Ezponda; Mrinal Y Shah; Yupeng Zheng; Christine M Will; Eliza C Small; Youjia Hua; Marinka Bulic; Yanwen Jiang; Matteo Carrara; Raffaele A Calogero; William L Kath; Neil L Kelleher; Ji-Ping Wang; Olivier Elemento; Jonathan D Licht
Journal:  PLoS Genet       Date:  2014-09-04       Impact factor: 5.917

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Journal:  Sci Rep       Date:  2017-02-22       Impact factor: 4.379

7.  Seven Genes Based Novel Signature Predicts Clinical Outcome and Platinum Sensitivity of High Grade IIIc Serous Ovarian Carcinoma.

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8.  NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.

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  8 in total

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