Literature DB >> 23565645

Mechanical properties of cellulose: chitosan blends for potential use as a coronary artery bypass graft.

Eduardo P Azevedo1, Rohini Retarekar, Madhavan L Raghavan, Vijay Kumar.   

Abstract

The development of intimal hyperplasia is the major cause of failure of both autologous saphenous vein and synthetic coronary artery bypass grafts. This is partially due to graft-host vessel compliance mismatch. Cellulose and chitosan (CELL:CHIT) are both biocompatible, nontoxic, and naturally occurring biopolymers that have been used extensively for biomedical applications. Elastic properties of membranes made of CELL:CHIT blends with different ratios between each polymer were determined using uniaxial tests and the ratio that yielded the less stiff membrane was chosen to prepare a small diameter hollow tube. The presence of chitosan had a favorable impact on the elasticity of the membranes, where the CELL:CHIT 5:5 ratio showed the lowest Young's modulus. Small diameter tubular constructs were fabricated using this optimal CELL:CHIT ratio and the compliance was determined on samples with different wall thickness and internal diameter. The compliance of the hollow tube with inner diameter of 4 mm and wall thickness of 1.2 mm was found to be 5.91%/mmHg×10(-2), which is higher than those of Dacron, expanded polytetrafluorethylene, and saphenous vein, but very close to that of human coronary artery. Burst strength tests revealed that the tubes can withstand at least 300 mmHg. Finally, the tubes showed satisfactory cell attachment property when myofibroblast cells adhered and proliferated on the lumen of the samples.

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Year:  2012        PMID: 23565645     DOI: 10.1080/09205063.2012.690273

Source DB:  PubMed          Journal:  J Biomater Sci Polym Ed        ISSN: 0920-5063            Impact factor:   3.517


  5 in total

1.  In Vitro Mechanical Property Evaluation of Chitosan-Based Hydrogels Intended for Vascular Graft Development.

Authors:  Audrey Aussel; Alexandra Montembault; Sébastien Malaise; Marie Pierre Foulc; William Faure; Sandro Cornet; Rachida Aid; Marc Chaouat; Thierry Delair; Didier Letourneur; Laurent David; Laurence Bordenave
Journal:  J Cardiovasc Transl Res       Date:  2017-07-31       Impact factor: 4.132

2.  Paper-Based Substrate for a Surface-Enhanced Raman Spectroscopy Biosensing Platform-A Silver/Chitosan Nanocomposite Approach.

Authors:  Yuri Kang; Hyeok Jung Kim; Sung Hoon Lee; Hyeran Noh
Journal:  Biosensors (Basel)       Date:  2022-04-22

Review 3.  Natural-Fiber-Reinforced Chitosan, Chitosan Blends and Their Nanocomposites for Various Advanced Applications.

Authors:  Rushdan Ahmad Ilyas; Humaira Alias Aisyah; Abu Hassan Nordin; Norzita Ngadi; Mohamed Yusoff Mohd Zuhri; Muhammad Rizal Muhammad Asyraf; Salit Mohd Sapuan; Edi Syams Zainudin; Shubham Sharma; Hairul Abral; Mochamad Asrofi; Edi Syafri; Nasmi Herlina Sari; Mazlan Rafidah; Sharifah Zarina Syed Zakaria; Muhammad Rizal Razman; Nuriah Abd Majid; Zuliskandar Ramli; Ashraf Azmi; Sneh Punia Bangar; Rushdan Ibrahim
Journal:  Polymers (Basel)       Date:  2022-02-23       Impact factor: 4.329

4.  Functional Bionanocomposite Fibers of Chitosan Filled with Cellulose Nanofibers Obtained by Gel Spinning.

Authors:  Sofia Marquez-Bravo; Ingo Doench; Pamela Molina; Flor Estefany Bentley; Arnaud Kamdem Tamo; Renaud Passieux; Francisco Lossada; Laurent David; Anayancy Osorio-Madrazo
Journal:  Polymers (Basel)       Date:  2021-05-13       Impact factor: 4.329

5.  Close Packing of Cellulose and Chitosan in Regenerated Cellulose Fibers Improves Carbon Yield and Structural Properties of Respective Carbon Fibers.

Authors:  Hilda Zahra; Daisuke Sawada; Chamseddine Guizani; Yibo Ma; Shogo Kumagai; Toshiaki Yoshioka; Herbert Sixta; Michael Hummel
Journal:  Biomacromolecules       Date:  2020-09-17       Impact factor: 6.988

  5 in total

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