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Literature DB >> 23565128

Genetic animal models of preconditioning.

Abstract

The preconditioning phenomena have been well established in heart as well as brain. In this review, we detail some of the original studies on preconditioning as well as studies from our lab using rodents and a genetic model system (fruit fly). We have used Drosophila in our lab to solve some of the questions related to tolerance or susceptibility to hypoxia. We believe that these pro-survival strategies and genetic pathways help us understand some of the preconditioning mechanisms that protect the brain from ischemia or ischemia.

Entities: Chemical Disease Gene Species

Keywords: Preconditioning; fruit flies; genetic model; hypoxia tolerance

Mesh：

Year: 2012 PMID： 23565128 PMCID： PMC3614364 DOI： 10.1007/s12975-012-0218-1

Source DB: PubMed Journal: Transl Stroke Res ISSN： 1868-4483 Impact factor: 6.829

41 in total

1. Neuroprotective effect of hypoxic preconditioning: phenomenon and mechanisms.

Authors: V I Kulinskii; L N Minakina; T V Gavrilina
Journal: Bull Exp Biol Med Date: 2002-02 Impact factor: 0.804

2. Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemia.

Authors: M A Pérez-Pinzón; G P Xu; W D Dietrich; M Rosenthal; T J Sick
Journal: J Cereb Blood Flow Metab Date: 1997-02 Impact factor: 6.200

Genetic animal models of preconditioning.

1. Neuroprotective effect of hypoxic preconditioning: phenomenon and mechanisms.

2. Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemia.

3. Induced tolerance to ischemia in gerbil hippocampal neurons.

4. Cerebral protection by hypoxic preconditioning in a murine model of focal ischemia-reperfusion.

Review 5. [Brain mechanisms of hypoxic preconditioning].

Review 6. Ischaemic preconditioning of the brain, mechanisms and applications.

7. Ischemic preconditioning: a novel target for neuroprotective therapy.

Review 8. Molecular physiology of preconditioning-induced brain tolerance to ischemia.

9. Adaptation of adult brain tissue to anoxia and hypoxia in vitro.

10. Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster.

Review 1. Ischemic stroke and mitochondria: mechanisms and targets.

Review 2. Cerebral Ischemic Preconditioning: the Road So Far….

3. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism.