BACKGROUND: Fatty acid composition of adipose tissue is a most reliable biomarker of long-term dietary fatty acid intake. Few studies have implemented biomarkers of fatty acid intake in relation to breast cancer. In this study the relation between adipose tissue composition and breast cancer was investigated. PATIENTS AND METHODS: Fatty acid composition in breast and buttock adipose tissue from 94 Greek women with breast cancer and 57 with benign breast tumors was determined. Multivariate analysis was performed to determine the association between fatty acid groups and breast cancer risk. RESULTS: In pre-menopausal women, elevated total polyunsaturated fatty acids (PUFA) in breast adipose tissue and N-3 PUFA in buttock adipose tissue were associated with reduced odds of breast cancer (odds ratio, OR=0.19; 95% confidence interval, CI=0.05-0.76, p<0.02 and OR=0.02; 95% CI=0.0009-0.36, p<0.009). CONCLUSION: Adipose total PUFA and N-3 PUFA were inversely-related to breast cancer risk in Greek pre-menopausal women. These results may have specific impact on habitual fat intake recommendations.
BACKGROUND:Fatty acid composition of adipose tissue is a most reliable biomarker of long-term dietary fatty acid intake. Few studies have implemented biomarkers of fatty acid intake in relation to breast cancer. In this study the relation between adipose tissue composition and breast cancer was investigated. PATIENTS AND METHODS: Fatty acid composition in breast and buttock adipose tissue from 94 Greek women with breast cancer and 57 with benign breast tumors was determined. Multivariate analysis was performed to determine the association between fatty acid groups and breast cancer risk. RESULTS: In pre-menopausal women, elevated total polyunsaturated fatty acids (PUFA) in breast adipose tissue and N-3 PUFA in buttock adipose tissue were associated with reduced odds of breast cancer (odds ratio, OR=0.19; 95% confidence interval, CI=0.05-0.76, p<0.02 and OR=0.02; 95% CI=0.0009-0.36, p<0.009). CONCLUSION: Adipose total PUFA and N-3 PUFA were inversely-related to breast cancer risk in Greek pre-menopausal women. These results may have specific impact on habitual fat intake recommendations.
Authors: Melanie Freed; Pippa Storey; Alana Amarosa Lewin; James Babb; Melanie Moccaldi; Linda Moy; Sungheon G Kim Journal: Radiology Date: 2016-06-07 Impact factor: 11.105
Authors: J A Schmidt; A Gorst-Rasmussen; P W Nyström; J H Christensen; E B Schmidt; C Dethlefsen; A Tjønneland; K Overvad; C C Dahm Journal: Eur J Clin Nutr Date: 2014-03-19 Impact factor: 4.016
Authors: Vasiliki Mallikourti; Sai Man Cheung; Tanja Gagliardi; Nicholas Senn; Yazan Masannat; Trevor McGoldrick; Ravi Sharma; Steven D Heys; Jiabao He Journal: Sci Rep Date: 2020-11-18 Impact factor: 4.379