Literature DB >> 235644

Cardioselective beta-adrenergic blocking agents. 1. 1-((3,4-Dimethoxyphenethyl)amino)-3-aryloxy-2-propanols.

M L Hoefle, S G Hastings, R F Meyer, R M Corey, A Holmes, C D Stratton.   

Abstract

A series of 1-amino-3-aryloxy-2-propanols has been synthesized and examined for cardioselective beta-blockade. The introduction of the (3,4-dimethoxyphenethyl)amino group lead to the most cardioselective agents. Structure-activity relationships are discussed. Of the compounds tested 1-[(3,4-dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol was selected for clinical trial because of optimal potency and selectivity.

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Year:  1975        PMID： 235644     DOI： 10.1021/jm00236a007

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  9 in total

1.  In vitro activity of RO363, a beta1-adrenoceptor selective agonist.

Authors:  D Iakovidis; E Malta; G A McPherson; C Raper
Journal:  Br J Pharmacol       Date:  1980-04       Impact factor: 8.739

2.  A high-performance liquid chromatographic assay for the enantiomers of bevantolol in human plasma.

Authors:  S E Rose; E J Randinitis
Journal:  Pharm Res       Date:  1991-06       Impact factor: 4.200

3.  Effects of prenalterol and its N-homoveratryl derivative in the anaesthetized cat.

Authors:  C Maccarrone; E Malta; C Raper
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-07       Impact factor: 3.000

4.  The influence of molecular structure on the affinity and efficacy of some beta-adrenoceptor agonists.

Authors:  P Molenaar; G A McPherson; E Malta; C Raper
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

5.  Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum.

Authors:  J W Growcott; C Wilson; B Holloway; S Mainwaring
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

6.  Atypical cardiostimulant beta-adrenoceptor in the rat heart: stereoselective antagonism by bupranolol but lack of effect by some bupranolol analogues.

Authors:  Barbara Malinowska; Katarzyna Kieć-Kononowicz; Karsten Flau; Grzegorz Godlewski; Hanna Kozłowska; Markus Kathmann; Eberhard Schlicker
Journal:  Br J Pharmacol       Date:  2003-08       Impact factor: 8.739

7.  Cardiovascular effects of bevantolol, a selective beta 1-adrenoceptor antagonist with a novel pharmacological profile.

Authors:  I D Dukes; E M Vaughan Williams
Journal:  Br J Pharmacol       Date:  1985-02       Impact factor: 8.739

8.  Pharmacokinetic parameters of bevantolol in volunteers.

Authors:  P Vermeij; P van Brummelen
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

9.  Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.

Authors:  Shailesh N Mistry; Jillian G Baker; Peter M Fischer; Stephen J Hill; Sheila M Gardiner; Barrie Kellam
Journal:  J Med Chem       Date:  2013-05-10       Impact factor: 7.446
  9 in total

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