| Literature DB >> 23563543 |
Chinatsu Kawada1, Tatsuya Hasegawa, Mutsuto Watanabe, Yoshihiro Nomura.
Abstract
Dietary glucosylceramide increased the expression of claudin-1 in UVB-irradiated mouse epidermis. Sphingosine and phytosphingosine, metabolites of glucosylceramide, increased trans-epithelial electrical resistance, and phytosphingosine increased claudin-1 mRNA expression in cultured keratinocytes. Our results indicate that the skin barrier improvement induced by dietary glucosylceramide might be due to enhancement of tight junction function, mediated by increased expression of claudin-1 induced by sphingoid metabolites.Entities:
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Year: 2013 PMID: 23563543 DOI: 10.1271/bbb.120874
Source DB: PubMed Journal: Biosci Biotechnol Biochem ISSN: 0916-8451 Impact factor: 2.043