Literature DB >> 23563284

Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers.

Dion van der Born1, J Koos D M Herscheid, Romano V A Orru, Danielle J Vugts.   

Abstract

A new strategy towards [(18)F]trifluoromethyl-containing compounds is developed. [(18)F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [(18)F]trifluoromethyl carbinols in good yields.

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Year:  2013        PMID： 23563284     DOI： 10.1039/c3cc37833k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

Review 1.  Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

Authors:  Victor W Pike
Journal:  Curr Med Chem       Date:  2016       Impact factor: 4.530

Review 2.  Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions.

Authors:  Xiaoyun Deng; Jian Rong; Lu Wang; Neil Vasdev; Lei Zhang; Lee Josephson; Steven H Liang
Journal:  Angew Chem Int Ed Engl       Date:  2019-01-14       Impact factor: 15.336

3.  [11 C]Fluoroform, a Breakthrough for Versatile Labeling of PET Radiotracer Trifluoromethyl Groups in High Molar Activity.

Authors:  Mohammad B Haskali; Victor W Pike
Journal:  Chemistry       Date:  2017-05-17       Impact factor: 5.236

4.  Evaluating N-difluoromethyltriazolium triflate as a precursor for the synthesis of high molar activity [18 F]fluoroform.

Authors:  Anna Pees; Maria J W D Vosjan; Jin Young Chai; Hyojin Cha; Dae Yoon Chi; Albert D Windhorst; Danielle J Vugts
Journal:  J Labelled Comp Radiopharm       Date:  2021-09-20       Impact factor: 1.949

Review 5.  18F-labelled intermediates for radiosynthesis by modular build-up reactions: newer developments.

Authors:  Johannes Ermert
Journal:  Biomed Res Int       Date:  2014-06-23       Impact factor: 3.411

Review 6.  Radiosynthesis of [18)F]trifluoroalkyl groups: scope and limitations.

Authors:  V T Lien; P J Riss
Journal:  Biomed Res Int       Date:  2014-07-10       Impact factor: 3.411

7.  Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated 18F-trifluoromethylation procedure.

Authors:  Alice King; Andreas Doepner; David Turton; Daniela M Ciobota; Chiara Da Pieve; Anne-Christine Wong Te Fong; Gabriela Kramer-Marek; Yuen-Li Chung; Graham Smith
Journal:  Org Biomol Chem       Date:  2018-04-25       Impact factor: 3.876

8.  A Gas Phase Route to [18F]fluoroform with Limited Molar Activity Dilution.

Authors:  Bo Yeun Yang; Sanjay Telu; Mohammad B Haskali; Cheryl L Morse; Victor W Pike
Journal:  Sci Rep       Date:  2019-10-16       Impact factor: 4.379

9.  Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system.

Authors:  Yamato Fujihira; Yumeng Liang; Makoto Ono; Kazuki Hirano; Takumi Kagawa; Norio Shibata
Journal:  Beilstein J Org Chem       Date:  2021-02-12       Impact factor: 2.883

Review 10.  Advances in [18F]Trifluoromethylation Chemistry for PET Imaging.

Authors:  Felix Francis; Frank Wuest
Journal:  Molecules       Date:  2021-10-27       Impact factor: 4.411
  10 in total

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