| Literature DB >> 23562658 |
Jiong Ni1, Peijun Wang, Jingfa Zhang, Wei Chen, Limin Gu.
Abstract
P2X7 receptor (P2X7R) is an ATP-gated cation channel that promotes microglia activation and plays a critical role in the pathogenesis of Alzheimer's disease. Inhibiting P2X7R indirectly reduces the rate of amyloid-β (Aβ)-induced neurodegeneration by suppressing secretion of inflammatory factors from activated microglia. We used RNA interference to silence P2X7R in microglial cells in vitro and found it markedly increased microglial phagocytosis of Aβ1-42. Increased phagocytic activity was dependent on decreasing the rate of interleukin-1β release from microglia and required inhibition of the COX-2 pathway. Modulation of microglial phagocytosis and secretion via silencing P2X7R may be a promising therapeutic option for the treatment of Alzheimer's disease.Entities:
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Year: 2013 PMID： 23562658 DOI： 10.1016/j.bbrc.2013.03.079
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575