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Literature DB >> 23562475

The SxxSS motif of T-cell factor-4 isoforms modulates Wnt/β-catenin signal activation in hepatocellular carcinoma cells.

Yoshito Tomimaru¹, Hironori Koga, Tai Ho Shin, Chelsea Q Xu, Jack R Wands, Miran Kim.

Abstract

T-cell factor (TCF) proteins represent key transcription factors in Wnt signaling. We show that the SxxSS motif in TCF-4 regulates transcriptional activity in HCC cells. TCF-4K mutants increased transcriptional activity compared to TCF-4K (bearing the SxxSS); the binding pattern of co-factors in TCF-4K mutants was similar to that in TCF-4J (lacking the SxxSS). TCF activity in TCF-4K cells was suppressed by homeodomain-interacting protein kinase 2 (HIPK2), but not in TCF-4J cells. Together, our data indicates that the SxxSS motif in TCF-4K regulates transcriptional activity by modifying co-factors in the β-catenin/TCF-4 transcriptional complex and these events may be mediated through HIPK2.

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Year: 2013 PMID： 23562475 PMCID： PMC3700609 DOI： 10.1016/j.canlet.2013.03.031

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

39 in total

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Review 5. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.

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8. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells.

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The SxxSS motif of T-cell factor-4 isoforms modulates Wnt/β-catenin signal activation in hepatocellular carcinoma cells.

Review 1. Wnt/beta-catenin signaling in development and disease.

Review 2. Colorectal cancer and genetic alterations in the Wnt pathway.

Review 3. Mammalian Groucho homologs: redundancy or specificity?

4. Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation.

Review 5. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.

6. Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression.

7. HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.

8. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells.

9. Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma.

10. Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2.

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