Literature DB >> 2356243

A novel N6-substituted adenosine isolated from mi huan jun (Armillaria mellea) as a cerebral-protecting compound.

N Watanabe1, T Obuchi, M Tamai, H Araki, S Omura, J S Yang, D Q Yu, X T Liang, J H Huan.   

Abstract

Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridyl-methylamino)-9-beta-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra.

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Year:  1990        PMID: 2356243     DOI: 10.1055/s-2006-960882

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  1 in total

1.  Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder.

Authors:  Zhong-lin Huang; Rui Liu; Xiao-yu Bai; Gang Zhao; Jun-ke Song; Song Wu; Guan-hua Du
Journal:  Acta Pharmacol Sin       Date:  2013-12-16       Impact factor: 6.150

  1 in total

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