Literature DB >> 23562072

Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration.

Jing Chen1, Lois E H Smith.   

Abstract

Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23562072      PMCID： PMC3669899          DOI： 10.1016/j.cmet.2013.03.010

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.

Authors:  Wei Chen; Dwight Stambolian; Albert O Edwards; Kari E Branham; Mohammad Othman; Johanna Jakobsdottir; Nirubol Tosakulwong; Margaret A Pericak-Vance; Peter A Campochiaro; Michael L Klein; Perciliz L Tan; Yvette P Conley; Atsuhiro Kanda; Laura Kopplin; Yanming Li; Katherine J Augustaitis; Athanasios J Karoukis; William K Scott; Anita Agarwal; Jaclyn L Kovach; Stephen G Schwartz; Eric A Postel; Matthew Brooks; Keith H Baratz; William L Brown; Alexander J Brucker; Anton Orlin; Gary Brown; Allen Ho; Carl Regillo; Larry Donoso; Lifeng Tian; Brian Kaderli; Dexter Hadley; Stephanie A Hagstrom; Neal S Peachey; Ronald Klein; Barbara E K Klein; Norimoto Gotoh; Kenji Yamashiro; Frederick Ferris Iii; Jesen A Fagerness; Robyn Reynolds; Lindsay A Farrer; Ivana K Kim; Joan W Miller; Marta Cortón; Angel Carracedo; Manuel Sanchez-Salorio; Elizabeth W Pugh; Kimberly F Doheny; Maria Brion; Margaret M Deangelis; Daniel E Weeks; Donald J Zack; Emily Y Chew; John R Heckenlively; Nagahisa Yoshimura; Sudha K Iyengar; Peter J Francis; Nicholas Katsanis; Johanna M Seddon; Jonathan L Haines; Michael B Gorin; Gonçalo R Abecasis; Anand Swaroop
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-12       Impact factor: 11.205

2.  Complement factor H polymorphism in age-related macular degeneration.

Authors:  Robert J Klein; Caroline Zeiss; Emily Y Chew; Jen-Yue Tsai; Richard S Sackler; Chad Haynes; Alice K Henning; John Paul SanGiovanni; Shrikant M Mane; Susan T Mayne; Michael B Bracken; Frederick L Ferris; Jurg Ott; Colin Barnstable; Josephine Hoh
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

3.  MiR-33 contributes to the regulation of cholesterol homeostasis.

Authors:  Katey J Rayner; Yajaira Suárez; Alberto Dávalos; Saj Parathath; Michael L Fitzgerald; Norimasa Tamehiro; Edward A Fisher; Kathryn J Moore; Carlos Fernández-Hernando
Journal:  Science       Date:  2010-05-13       Impact factor: 47.728

4.  NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.

Authors:  Sarah L Doyle; Matthew Campbell; Ema Ozaki; Robert G Salomon; Andres Mori; Paul F Kenna; Gwyneth Jane Farrar; Anna-Sophia Kiang; Marian M Humphries; Ed C Lavelle; Luke A J O'Neill; Joe G Hollyfield; Peter Humphries
Journal:  Nat Med       Date:  2012-05       Impact factor: 53.440

5.  CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

Authors:  Christophe Combadière; Charles Feumi; William Raoul; Nicole Keller; Mathieu Rodéro; Adeline Pézard; Sophie Lavalette; Marianne Houssier; Laurent Jonet; Emilie Picard; Patrice Debré; Mirna Sirinyan; Philippe Deterre; Tania Ferroukhi; Salomon-Yves Cohen; Dominique Chauvaud; Jean-Claude Jeanny; Sylvain Chemtob; Francine Behar-Cohen; Florian Sennlaub
Journal:  J Clin Invest       Date:  2007-10       Impact factor: 14.808

6.  Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

Authors:  Abdoulaye Sene; Aslam A Khan; Douglas Cox; Rei E I Nakamura; Andrea Santeford; Bryan M Kim; Rohini Sidhu; Michael D Onken; J William Harbour; Shira Hagbi-Levi; Itay Chowers; Peter A Edwards; Angel Baldan; John S Parks; Daniel S Ory; Rajendra S Apte
Journal:  Cell Metab       Date:  2013-04-02       Impact factor: 27.287

Review 7.  Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration.

Authors:  Christine A Curcio; Mark Johnson; Jiahn-Dar Huang; Martin Rudolf
Journal:  J Lipid Res       Date:  2009-09-29       Impact factor: 5.922

8.  DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

Authors:  Valeria Tarallo; Yoshio Hirano; Bradley D Gelfand; Sami Dridi; Nagaraj Kerur; Younghee Kim; Won Gil Cho; Hiroki Kaneko; Benjamin J Fowler; Sasha Bogdanovich; Romulo J C Albuquerque; William W Hauswirth; Vince A Chiodo; Jennifer F Kugel; James A Goodrich; Steven L Ponicsan; Gautam Chaudhuri; Michael P Murphy; Joshua L Dunaief; Balamurali K Ambati; Yuichiro Ogura; Jae Wook Yoo; Dong-ki Lee; Patrick Provost; David R Hinton; Gabriel Núñez; Judit Z Baffi; Mark E Kleinman; Jayakrishna Ambati
Journal:  Cell       Date:  2012-04-26       Impact factor: 41.582

9.  The controversy over the association between statins use and progression of age-related macular degeneration: a mini review.

Authors:  Vasileios Peponis; Spyridon E Chalkiadakis; Stefanos Bonovas; Nikolaos M Sitaras
Journal:  Clin Ophthalmol       Date:  2010-08-09

10.  Seven new loci associated with age-related macular degeneration.

Authors:  Lars G Fritsche; Wei Chen; Matthew Schu; Brian L Yaspan; Yi Yu; Gudmar Thorleifsson; Donald J Zack; Satoshi Arakawa; Valentina Cipriani; Stephan Ripke; Robert P Igo; Gabriëlle H S Buitendijk; Xueling Sim; Daniel E Weeks; Robyn H Guymer; Joanna E Merriam; Peter J Francis; Gregory Hannum; Anita Agarwal; Ana Maria Armbrecht; Isabelle Audo; Tin Aung; Gaetano R Barile; Mustapha Benchaboune; Alan C Bird; Paul N Bishop; Kari E Branham; Matthew Brooks; Alexander J Brucker; William H Cade; Melinda S Cain; Peter A Campochiaro; Chi-Chao Chan; Ching-Yu Cheng; Emily Y Chew; Kimberly A Chin; Itay Chowers; David G Clayton; Radu Cojocaru; Yvette P Conley; Belinda K Cornes; Mark J Daly; Baljean Dhillon; Albert O Edwards; Evangelos Evangelou; Jesen Fagerness; Henry A Ferreyra; James S Friedman; Asbjorg Geirsdottir; Ronnie J George; Christian Gieger; Neel Gupta; Stephanie A Hagstrom; Simon P Harding; Christos Haritoglou; John R Heckenlively; Frank G Holz; Guy Hughes; John P A Ioannidis; Tatsuro Ishibashi; Peronne Joseph; Gyungah Jun; Yoichiro Kamatani; Nicholas Katsanis; Claudia N Keilhauer; Jane C Khan; Ivana K Kim; Yutaka Kiyohara; Barbara E K Klein; Ronald Klein; Jaclyn L Kovach; Igor Kozak; Clara J Lee; Kristine E Lee; Peter Lichtner; Andrew J Lotery; Thomas Meitinger; Paul Mitchell; Saddek Mohand-Saïd; Anthony T Moore; Denise J Morgan; Margaux A Morrison; Chelsea E Myers; Adam C Naj; Yusuke Nakamura; Yukinori Okada; Anton Orlin; M Carolina Ortube; Mohammad I Othman; Chris Pappas; Kyu Hyung Park; Gayle J T Pauer; Neal S Peachey; Olivier Poch; Rinki Ratna Priya; Robyn Reynolds; Andrea J Richardson; Raymond Ripp; Guenther Rudolph; Euijung Ryu; José-Alain Sahel; Debra A Schaumberg; Hendrik P N Scholl; Stephen G Schwartz; William K Scott; Humma Shahid; Haraldur Sigurdsson; Giuliana Silvestri; Theru A Sivakumaran; R Theodore Smith; Lucia Sobrin; Eric H Souied; Dwight E Stambolian; Hreinn Stefansson; Gwen M Sturgill-Short; Atsushi Takahashi; Nirubol Tosakulwong; Barbara J Truitt; Evangelia E Tsironi; André G Uitterlinden; Cornelia M van Duijn; Lingam Vijaya; Johannes R Vingerling; Eranga N Vithana; Andrew R Webster; H-Erich Wichmann; Thomas W Winkler; Tien Y Wong; Alan F Wright; Diana Zelenika; Ming Zhang; Ling Zhao; Kang Zhang; Michael L Klein; Gregory S Hageman; G Mark Lathrop; Kari Stefansson; Rando Allikmets; Paul N Baird; Michael B Gorin; Jie Jin Wang; Caroline C W Klaver; Johanna M Seddon; Margaret A Pericak-Vance; Sudha K Iyengar; John R W Yates; Anand Swaroop; Bernhard H F Weber; Michiaki Kubo; Margaret M Deangelis; Thierry Léveillard; Unnur Thorsteinsdottir; Jonathan L Haines; Lindsay A Farrer; Iris M Heid; Gonçalo R Abecasis
Journal:  Nat Genet       Date:  2013-03-03       Impact factor: 38.330
  10 in total
  3 in total

1.  An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD.

Authors:  Seyedeh Maryam Zekavat; James Lu; Cyrille Maugeais; Norman A Mazer
Journal:  J Lipid Res       Date:  2017-04-25       Impact factor: 5.922

2.  Bioinformatical Analysis of miRNA-mRNA Interaction Network Underlying Macrophage Aging and Cholesterol-Responsive Difference between Young and Aged Macrophages.

Authors:  Jianqing Li; Xue Yin; Bingyu Zhang; Chen Li; Peirong Lu
Journal:  Biomed Res Int       Date:  2020-06-12       Impact factor: 3.411

Review 3.  Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks.

Authors:  Francesco Parmeggiani; Francesco S Sorrentino; Mario R Romano; Ciro Costagliola; Francesco Semeraro; Carlo Incorvaia; Sergio D'Angelo; Paolo Perri; Katia De Nadai; Elia Bonomo Roversi; Paola Franceschelli; Adolfo Sebastiani; Michele Rubini
Journal:  Mediators Inflamm       Date:  2013-11-27       Impact factor: 4.711
  3 in total

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