Literature DB >> 23560011

Intracerebral metastasis in pediatric acute lymphoblastic leukemia: A rare presentation.

Müge Gokce1, Selin Aytac, Ilhan Altan, Sule Unal, Murat Tuncer, Fatma Gumruk, Mualla Cetin.   

Abstract

Central nervous system leukemia may present in different ways. However, intraparenchymal mass is extremely rare in childhood leukemia. Herein, we report a boy who presented with right hemiparesis and anisocoria 1 year after the cessation of the chemotherapy protocol for acute lymphoblastic leukemia. Cranial imaging demonstrated an extensive mass located in the anterior white matter of left frontal lobe, and cerebrospinal fluid examination revealed concomitant lymphoblasts. Immunohistochemical staining of the biopsy material showed neoplastic cells with positive CD10 and TdT. Complete remission was achieved with chemotherapy alone for a duration of 2 years.

Entities:  

Keywords:  Acute lymphoblastic leukemia; central nervous system relapse; intracerebral mass

Year:  2012        PMID： 23560011      PMCID： PMC3611913          DOI： 10.4103/1817-1745.106482

Source DB:  PubMed          Journal:  J Pediatr Neurosci        ISSN： 1817-1745


  14 in total

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3.  Co-occurrence of TCF3-PBX1 gene fusion, and chromosomal aberration in a pediatric pre-B cell acute lymphoblastic leukemia with clitoris swelling: A case report and literature review.

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