OBJECTIVES: African Americans (AA) have substantially lower levels of circulating 25-hydroxyvitamin D (25(OH)D) than whites. We compared population-based samples of 25(OH)D in women of African descent from Nigeria and metropolitan Chicago. METHODS: One hundred women of Yoruba ethnicity from southwest Nigeria and 94 African American women from metropolitan Chicago were recruited and compared using a standardized survey protocol and the same laboratory assay for 25(OH)D. RESULTS: Mean 25(OH)D levels were 64 nmol/l among the Nigerians and 29 nmol/l among the AA. Only 10% of the values were shared in common between the groups, and 76% of the Nigerians were above the currently defined threshold for adequate circulating 25(OH)D compared to 5% of the AA. Modest associations were seen between 25(OH)D and measures of obesity, although adjustment for these traits did not materially affect the group differences. CONCLUSION: These data support the presumption that skin color is an adaptive trait which has evolved in part to regulate 25(OH)D. It remains undetermined, however, whether lower values observed in AA have negative health consequences.
OBJECTIVES: African Americans (AA) have substantially lower levels of circulating 25-hydroxyvitamin D (25(OH)D) than whites. We compared population-based samples of 25(OH)D in women of African descent from Nigeria and metropolitan Chicago. METHODS: One hundred women of Yoruba ethnicity from southwest Nigeria and 94 African American women from metropolitan Chicago were recruited and compared using a standardized survey protocol and the same laboratory assay for 25(OH)D. RESULTS: Mean 25(OH)D levels were 64 nmol/l among the Nigerians and 29 nmol/l among the AA. Only 10% of the values were shared in common between the groups, and 76% of the Nigerians were above the currently defined threshold for adequate circulating 25(OH)D compared to 5% of the AA. Modest associations were seen between 25(OH)D and measures of obesity, although adjustment for these traits did not materially affect the group differences. CONCLUSION: These data support the presumption that skin color is an adaptive trait which has evolved in part to regulate 25(OH)D. It remains undetermined, however, whether lower values observed in AA have negative health consequences.
Authors: Lisa B Signorello; Scott M Williams; Wei Zheng; Jeffrey R Smith; Jirong Long; Qiuyin Cai; Margaret K Hargreaves; Bruce W Hollis; William J Blot Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-07-20 Impact factor: 4.254
Authors: Michal L Melamed; Brad Astor; Erin D Michos; Thomas H Hostetter; Neil R Powe; Paul Muntner Journal: J Am Soc Nephrol Date: 2009-10-29 Impact factor: 10.121
Authors: Anne C Looker; Clifford L Johnson; David A Lacher; Christine M Pfeiffer; Rosemary L Schleicher; Christopher T Sempos Journal: NCHS Data Brief Date: 2011-03
Authors: Kara E Ebersole; Lara R Dugas; Ramon A Durazo-Arvizut; Adebowale A Adeyemo; Bamidele O Tayo; Olayemi O Omotade; William R Brieger; Dale A Schoeller; Richard S Cooper; Amy H Luke Journal: Obesity (Silver Spring) Date: 2008-09 Impact factor: 5.002
Authors: G D Carter; C R Carter; E Gunter; J Jones; G Jones; H L J Makin; S Sufi Journal: J Steroid Biochem Mol Biol Date: 2004-05 Impact factor: 4.292
Authors: Susan J van Rensburg; Ronald van Toorn; Kelebogile E Moremi; Armand V Peeters; Adesola Oguniyi; Maritha J Kotze Journal: Metab Brain Dis Date: 2016-01-08 Impact factor: 3.584
Authors: Ramon A Durazo-Arvizu; Pauline Camacho; Pascal Bovet; Terrence Forrester; Estelle V Lambert; Jacob Plange-Rhule; Andrew N Hoofnagle; John Aloia; Bamidele Tayo; Lara R Dugas; Richard S Cooper; Amy Luke Journal: Am J Clin Nutr Date: 2014-07-09 Impact factor: 7.045
Authors: Paulette D Chandler; Edward L Giovannucci; Jamil B Scott; Gary G Bennett; Kimmie Ng; Andrew T Chan; Bruce W Hollis; Nader Rifai; Karen M Emmons; Charles S Fuchs; Bettina F Drake Journal: Sci Rep Date: 2015-06-22 Impact factor: 4.379
Authors: P D Chandler; J B Scott; B F Drake; K Ng; A T Chan; B W Hollis; K M Emmons; E L Giovannucci; C S Fuchs; G G Bennett Journal: Nutr Diabetes Date: 2015-01-19 Impact factor: 5.097
Authors: Bamidele O Tayo; Titilola S Akingbola; Babatunde L Salako; Colin A McKenzie; Marvin Reid; Jennifer Layden; Ifeyinwa Osunkwo; Jacob Plange-Rhule; Amy Luke; Ramon Durazo-Arvizu; Richard S Cooper Journal: BMC Hematol Date: 2014-08-16