INTRODUCTION: Severe neurological symptoms in Shiga toxin-producing Escherichia coli infection associated hemolytic-uremic syndrome (STEC-HUS) are often accompanied by none or only mild alterations of cerebral magnetic resonance imaging (MRI). This study aims to analyze if quantitative MRI is able to reveal cerebral pathological alterations invisible for conventional MRI. METHODS: In nine patients with STEC-HUS associated severe neurological symptoms but inconspicuous cerebral MRI findings maps of the parameters T2 relaxation time, relative proton density (PD), apparent diffusion coefficient (ADC), and fractional anisotropy (FA) were generated. Quantitative values of these parameters were measured at the basal ganglia, thalamus, and white matter of the frontal and parietal lobe and compared to those of nine age- and sex-matched controls. RESULTS: Significant T2 prolongation (p < 0.01) was found in the basal ganglia of all patients compared to controls. PD and ADC were not significantly altered. A significant reduction of FA in patients was seen at caput nuclei caudati (p < 0.01). CONCLUSION: Prolonged T2 relaxation time indicates cerebral microstructural damages in these patients despite their inconspicuous MRI findings. T2 relaxometry could be used as a complementary tool for the assessment of metabolic-toxic brain syndromes.
INTRODUCTION: Severe neurological symptoms in Shiga toxin-producing Escherichia coli infection associated hemolytic-uremic syndrome (STEC-HUS) are often accompanied by none or only mild alterations of cerebral magnetic resonance imaging (MRI). This study aims to analyze if quantitative MRI is able to reveal cerebral pathological alterations invisible for conventional MRI. METHODS: In nine patients with STEC-HUS associated severe neurological symptoms but inconspicuous cerebral MRI findings maps of the parameters T2 relaxation time, relative proton density (PD), apparent diffusion coefficient (ADC), and fractional anisotropy (FA) were generated. Quantitative values of these parameters were measured at the basal ganglia, thalamus, and white matter of the frontal and parietal lobe and compared to those of nine age- and sex-matched controls. RESULTS: Significant T2 prolongation (p < 0.01) was found in the basal ganglia of all patients compared to controls. PD and ADC were not significantly altered. A significant reduction of FA in patients was seen at caput nuclei caudati (p < 0.01). CONCLUSION: Prolonged T2 relaxation time indicates cerebral microstructural damages in these patients despite their inconspicuous MRI findings. T2 relaxometry could be used as a complementary tool for the assessment of metabolic-toxic brain syndromes.
Authors: Andreas Bauwens; Martina Bielaszewska; Björn Kemper; Patrik Langehanenberg; Gert von Bally; Rudolf Reichelt; Dennis Mulac; Hans-Ulrich Humpf; Alexander W Friedrich; Kwang S Kim; Helge Karch; Johannes Müthing Journal: Thromb Haemost Date: 2010-12-06 Impact factor: 5.249
Authors: Frank Donnerstag; Xiaoqi Ding; Lars Pape; Eva Bültmann; Thomas Lücke; Jan Zajaczek; Ludwig Hoy; Anibh Martin Das; Heinrich Lanfermann; Jochen Ehrich; Hans Hartmann Journal: Eur Radiol Date: 2011-10-08 Impact factor: 5.315
Authors: Xiao-Qi Ding; Thomas Kucinski; Oliver Wittkugel; Einar Goebell; Ulrich Grzyska; Maria Görg; Alfried Kohlschütter; Hermann Zeumer Journal: Invest Radiol Date: 2004-12 Impact factor: 6.016
Authors: V V Eylers; A A Maudsley; P Bronzlik; P R Dellani; H Lanfermann; X-Q Ding Journal: AJNR Am J Neuroradiol Date: 2015-11-12 Impact factor: 3.825
Authors: Alexander Lukasz; Jan Beneke; Kristina Thamm; Jan T Kielstein; Jan Menne; Jan-Henrik Mikesch; Bernhard M W Schmidt; Hermann Haller; Philipp Kümpers; Sascha David; Mario Schiffer Journal: Mediators Inflamm Date: 2015-12-24 Impact factor: 4.711
Authors: Ramona Schuppner; Justus Maehlmann; Meike Dirks; Hans Worthmann; Anita B Tryc; Kajetan Sandorski; Elisabeth Bahlmann; Jan T Kielstein; Anja M Giesemann; Heinrich Lanfermann; Karin Weissenborn Journal: Medicine (Baltimore) Date: 2016-02 Impact factor: 1.817