Literature DB >> 2355925

Identification of a G1-S-phase-regulated region in the human thymidine kinase gene promoter.

H H Roehl1, S E Conrad.   

Abstract

We have identified a regulatory region in the human thymidine kinase gene promoter. A set of promoter deletion mutants was constructed, linked to the bacterial neomycin resistance gene, and stably transfected into Rat3 cells. It was shown that the region between 135 and 67 base pairs upstream of the cap site is required for conveying G1-S-phase regulation to the linked neo gene. In addition, primer extension assays demonstrated that the same transcriptional start sites were used in G1- and S-phase cells and in the various deletion mutants tested.

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Year:  1990        PMID： 2355925      PMCID： PMC360850          DOI： 10.1128/mcb.10.7.3834-3837.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  19 in total

1.  Induction of cellular thymidine kinase occurs at the mRNA level.

Authors:  P Stuart; M Ito; C Stewart; S E Conrad
Journal:  Mol Cell Biol       Date:  1985-06       Impact factor: 4.272

2.  Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor.

Authors:  M Wigler; A Pellicer; S Silverstein; R Axel
Journal:  Cell       Date:  1978-07       Impact factor: 41.582

3.  Genetic analysis of the human thymidine kinase gene promoter.

Authors:  J A Kreidberg; T J Kelly
Journal:  Mol Cell Biol       Date:  1986-08       Impact factor: 4.272

4.  Role of the promoter in the regulation of the thymidine kinase gene.

Authors:  S Travali; K E Lipson; D Jaskulski; E Lauret; R Baserga
Journal:  Mol Cell Biol       Date:  1988-04       Impact factor: 4.272

5.  Evidence for transcriptional and post-transcriptional control of the cellular thymidine kinase gene.

Authors:  C J Stewart; M Ito; S E Conrad
Journal:  Mol Cell Biol       Date:  1987-03       Impact factor: 4.272

6.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors:  P J Southern; P Berg
Journal:  J Mol Appl Genet       Date:  1982

7.  tk Enzyme expression in differentiating muscle cells is regulated through an internal segment of the cellular tk gene.

Authors:  G F Merrill; S D Hauschka; S L McKnight
Journal:  Mol Cell Biol       Date:  1984-09       Impact factor: 4.272

8.  Regulation of thymidine kinase enzyme level in serum-stimulated mouse 3T6 fibroblasts.

Authors:  L F Johnson; L G Rao; A J Muench
Journal:  Exp Cell Res       Date:  1982-03       Impact factor: 3.905

9.  Normal rat cell lines deficient in nuclear thymidine kinase.

Authors:  W C Topp
Journal:  Virology       Date:  1981-08       Impact factor: 3.616

10.  Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes.

Authors:  S P Eisenberg; D M Coen; S L McKnight
Journal:  Mol Cell Biol       Date:  1985-08       Impact factor: 4.272
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  13 in total

1.  Identification of a 70-base-pair cell cycle regulatory unit within the promoter of the human thymidine kinase gene and its interaction with cellular factors.

Authors:  Y K Kim; A S Lee
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

2.  Inducible proteins binding to the murine thymidine kinase promoter in late G1/S phase.

Authors:  Q P Dou; J L Fridovich-Keil; A B Pardee
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

3.  Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.

Authors:  M M Anderson; J Chen; C N Cole; S E Conrad
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

Review 4.  Current concepts in DRA gene regulation.

Authors:  J P Ting
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

5.  The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter.

Authors:  A L Means; J E Slansky; S L McMahon; M W Knuth; P J Farnham
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

6.  Regulation of the cellular thymidine kinase gene promoter in simian virus 40-infected cells.

Authors:  H H Roehl; M M Anderson; C S Mehigh; S E Conrad
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

7.  E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.

Authors:  D A Taylor; V B Kraus; J J Schwarz; E N Olson; W E Kraus
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

8.  Presence of regulatory sequences within intron 2 of the mouse thymidine kinase gene.

Authors:  H Rotheneder; M Grabner; E Wintersberger
Journal:  Nucleic Acids Res       Date:  1991-12-25       Impact factor: 16.971

9.  Temporal regulation of cyclin A-p107 and p33cdk2 complexes binding to a human thymidine kinase promoter element important for G1-S phase transcriptional regulation.

Authors:  L J Li; G S Naeve; A S Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

10.  Elevated levels of thymidine kinase 1 peptide in serum from patients with breast cancer.

Authors:  Lena Carlsson; Anders Larsson; Henrik Lindman
Journal:  Ups J Med Sci       Date:  2009       Impact factor: 2.384
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