Literature DB >> 23558361

The Vitamin D paradox: bone density testing in females aged 45 to 74 did not increase over a ten-year period despite a marked increase in testing for vitamin D.

K Bilinski1, S Boyages.   

Abstract

AIM: To determine whether increased vitamin D testing resulted in improved osteoporosis detection in Australian females aged 45-74 yr.
METHODS: Longitudinal analysis of bone densitometry, 25-hydroxyvitamin D (25(OH)D) and full blood count (FBC) testing between 2001 and 2011. The number and rate of tests per 100,000 individuals and benefit in dollars for bone densitometry, 25(OH)D and FBC from 2001-2011 for individuals aged 45-74 yr were obtained from Medicare Australia.
RESULTS: There was a disproportionate increase in 25(OH)D testing compared to bone density testing from 2001 to 2011, whereby 25(OH)D testing increased from 26,666 to 1.65 million p.a. and bone density testing increased from 41,453 to 66,100 p.a. Bone densitometry increased approximately 1.2 fold, whereas 25(OH)D testing increased by 55.2, 41.2 and 34.3 fold in females aged 45-54, 55-64 and 65-74 yr, respectively. This represents an increase in annual benefits from approximately $2.5-$4.1 million for bone density testing and $0.7-$40.5 million for 25(OH)D testing over the period.
CONCLUSIONS: This study demonstrates that improved detection of vitamin D deficiency is not being translated into better detection in at-risk women of the consequences of vitamin D deficiency on target organs such as bone. This failure to translate rising awareness and better detection of vitamin D deficiency into physiological outcomes is a massive missed opportunity for improved bone health and reduced fracture risk.We propose that clinical practice guidelines be introduced not only for the purpose of diagnosis and testing for vitamin D, but to include recommendations for bone health testing in at-risk individuals.

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Year:  2013        PMID: 23558361     DOI: 10.3275/8922

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN: 0391-4097            Impact factor:   4.256


  14 in total

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Authors:  E Michael Lewiecki; Andrew J Laster; Paul D Miller; John P Bilezikian
Journal:  J Bone Miner Res       Date:  2012-04       Impact factor: 6.741

3.  Preventing overdiagnosis: how to stop harming the healthy.

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Review 4.  The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.

Authors:  Clifford J Rosen; John S Adams; Daniel D Bikle; Dennis M Black; Marie B Demay; JoAnn E Manson; M Hassan Murad; Christopher S Kovacs
Journal:  Endocr Rev       Date:  2012-05-17       Impact factor: 19.871

Review 5.  Vitamin D deficiency.

Authors:  Michael F Holick
Journal:  N Engl J Med       Date:  2007-07-19       Impact factor: 91.245

6.  The rise and rise of vitamin D testing.

Authors:  Kellie Bilinski; Steven Boyages
Journal:  BMJ       Date:  2012-07-16

7.  The rising cost of vitamin D testing in Australia: time to establish guidelines for testing.

Authors:  Kellie L Bilinski; Steven C Boyages
Journal:  Med J Aust       Date:  2012-07-16       Impact factor: 7.738

8.  Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective.

Authors:  Kumaravel Rajakumar
Journal:  Pediatrics       Date:  2003-08       Impact factor: 7.124

9.  Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents.

Authors:  Claudie Berger; Lisa Langsetmo; Lawrence Joseph; David A Hanley; K Shawn Davison; Robert Josse; Nancy Kreiger; Alan Tenenhouse; David Goltzman
Journal:  CMAJ       Date:  2008-06-17       Impact factor: 8.262

10.  Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group.

Authors:  S R Cummings; M C Nevitt; W S Browner; K Stone; K M Fox; K E Ensrud; J Cauley; D Black; T M Vogt
Journal:  N Engl J Med       Date:  1995-03-23       Impact factor: 91.245

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  4 in total

1.  Vitamin D: not all is bad.

Authors:  S Minisola; C Cipriani; S Piemonte; A Scillitani; J Pepe
Journal:  J Endocrinol Invest       Date:  2014-08-10       Impact factor: 4.256

2.  Evidence of overtesting for vitamin D in Australia: an analysis of 4.5 years of Medicare Benefits Schedule (MBS) data.

Authors:  Kellie Bilinski; Steve Boyages
Journal:  BMJ Open       Date:  2013-06-20       Impact factor: 2.692

3.  Increase of vitamin D assays prescriptions and associated factors: a population-based cohort study.

Authors:  Pascal Caillet; Anne Goyer-Joos; Marie Viprey; Anne-Marie Schott
Journal:  Sci Rep       Date:  2017-09-04       Impact factor: 4.379

Review 4.  Clinical Management of Low Vitamin D: A Scoping Review of Physicians' Practices.

Authors:  Michelle Rockwell; Vivica Kraak; Matthew Hulver; John Epling
Journal:  Nutrients       Date:  2018-04-16       Impact factor: 5.717

  4 in total

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