Literature DB >> 23558171

Nuclear actin network assembly by formins regulates the SRF coactivator MAL.

Christian Baarlink1, Haicui Wang, Robert Grosse.   

Abstract

Formins are potent activators of actin filament assembly in the cytoplasm. In turn, cytoplasmic actin polymerization can promote release of actin from megakaryocytic acute leukemia (MAL) protein for serum response factor (SRF) transcriptional activity. We found that formins polymerized actin inside the mammalian nucleus to drive serum-dependent MAL-SRF activity. Serum stimulated rapid assembly of actin filaments within the nucleus in a formin-dependent manner. The endogenous formin mDia was regulated with an optogenetic tool, which allowed for photoreactive release of nuclear formin autoinhibition. Activated mDia promoted rapid and reversible nuclear actin network assembly, subsequent MAL nuclear accumulation, and SRF activity. Thus, a dynamic polymeric actin structure within the nucleus is part of the serum response.

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Year:  2013        PMID： 23558171     DOI： 10.1126/science.1235038

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  161 in total

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Journal:  Spermatogenesis       Date:  2015-06-29

Review 2.  Actin, actin-binding proteins, and actin-related proteins in the nucleus.

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Journal:  Eur J Cell Biol       Date:  2016-06-25       Impact factor: 4.492

4.  Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.

Authors:  Joe Swift; Irena L Ivanovska; Amnon Buxboim; Takamasa Harada; P C Dave P Dingal; Joel Pinter; J David Pajerowski; Kyle R Spinler; Jae-Won Shin; Manorama Tewari; Florian Rehfeldt; David W Speicher; Dennis E Discher
Journal:  Science       Date:  2013-08-30       Impact factor: 47.728

Review 5.  Role of the extracellular matrix in regulating stem cell fate.

Authors:  Fiona M Watt; Wilhelm T S Huck
Journal:  Nat Rev Mol Cell Biol       Date:  2013-07-10       Impact factor: 94.444

Review 6.  Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?

Authors:  P Bryant Chase; Mark P Szczypinski; Elliott P Soto
Journal:  J Muscle Res Cell Motil       Date:  2013-08-02       Impact factor: 2.698

Review 7.  What we talk about when we talk about nuclear actin.

Authors:  Brittany J Belin; R Dyche Mullins
Journal:  Nucleus       Date:  2013-08-08       Impact factor: 4.197

8.  Withdrawal from repeated morphine administration augments expression of the RhoA network in the nucleus accumbens to control synaptic structure.

Authors:  Michael E Cahill; Caleb J Browne; Junshi Wang; Peter J Hamilton; Yan Dong; Eric J Nestler
Journal:  J Neurochem       Date:  2018-09-26       Impact factor: 5.372

9.  Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.

Authors:  Sharolyn V Kawakami-Schulz; Angela M Verdoni; Shannon G Sattler; Erik Jessen; Winston W-Y Kao; Akihiro Ikeda; Sakae Ikeda
Journal:  Physiol Genomics       Date:  2014-02-18       Impact factor: 3.107

10.  A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.

Authors:  Yong Ho Bae; Keeley L Mui; Bernadette Y Hsu; Shu-Lin Liu; Alexandra Cretu; Ziba Razinia; Tina Xu; Ellen Puré; Richard K Assoian
Journal:  Sci Signal       Date:  2014-06-17       Impact factor: 8.192
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