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Literature DB >> 23556116

Targeted therapies through microRNAs: pulp or fiction?

Christian Langer, Frank G Rücker, Christian Buske, Hartmut Döhner, Florian Kuchenbauer.

Abstract

With the discovery of post-transcriptional silencing, the idea of targeted therapies became an approachable goal. The widespread involvement of microRNAs (miRNAs) was thought to be the magic bullet against multiple diseases. However, several hurdles, ranging from targeted delivery to side effects still have to be resolved. In this review, we discuss recent progress on delivery as well as current applications for miRNAs as therapeutic agents.

Keywords: cancer; delivery; microRNA; post-transcriptional gene silencing

Year: 2012 PMID： 23556116 PMCID： PMC3573433 DOI： 10.1177/2040620711432582

Source DB: PubMed Journal: Ther Adv Hematol ISSN： 2040-6207

45 in total

1. MicroRNA miR-125a controls hematopoietic stem cell number.

Authors: Shangqin Guo; Jun Lu; Rita Schlanger; Hao Zhang; Judy Y Wang; Michelle C Fox; Louise E Purton; Heather H Fleming; Bradley Cobb; Matthias Merkenschlager; Todd R Golub; David T Scadden
Journal: Proc Natl Acad Sci U S A Date: 2010-07-08 Impact factor: 11.205

2. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.

Authors: James O McNamara; Eran R Andrechek; Yong Wang; Kristi D Viles; Rachel E Rempel; Eli Gilboa; Bruce A Sullenger; Paloma H Giangrande
Journal: Nat Biotechnol Date: 2006-06-25 Impact factor: 54.908

3. RAS is regulated by the let-7 microRNA family.

Authors: Steven M Johnson; Helge Grosshans; Jaclyn Shingara; Mike Byrom; Rich Jarvis; Angie Cheng; Emmanuel Labourier; Kristy L Reinert; David Brown; Frank J Slack
Journal: Cell Date: 2005-03-11 Impact factor: 41.582

4. MicroRNA miR-125b causes leukemia.

Authors: Marina Bousquet; Marian H Harris; Beiyan Zhou; Harvey F Lodish
Journal: Proc Natl Acad Sci U S A Date: 2010-11-30 Impact factor: 11.205

5. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Authors: Jürgen Soutschek; Akin Akinc; Birgit Bramlage; Klaus Charisse; Rainer Constien; Mary Donoghue; Sayda Elbashir; Anke Geick; Philipp Hadwiger; Jens Harborth; Matthias John; Venkitasamy Kesavan; Gary Lavine; Rajendra K Pandey; Timothy Racie; Kallanthottathil G Rajeev; Ingo Röhl; Ivanka Toudjarska; Gang Wang; Silvio Wuschko; David Bumcrot; Victor Koteliansky; Stefan Limmer; Muthiah Manoharan; Hans-Peter Vornlocher
Journal: Nature Date: 2004-11-11 Impact factor: 49.962

6. c-Myc-regulated microRNAs modulate E2F1 expression.

Authors: Kathryn A O'Donnell; Erik A Wentzel; Karen I Zeller; Chi V Dang; Joshua T Mendell
Journal: Nature Date: 2005-06-09 Impact factor: 49.962

7. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis.

Authors: Mark Bloomston; Wendy L Frankel; Fabio Petrocca; Stefano Volinia; Hansjuerg Alder; John P Hagan; Chang-Gong Liu; Darshna Bhatt; Cristian Taccioli; Carlo M Croce
Journal: JAMA Date: 2007-05-02 Impact factor: 56.272

8. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

Authors: George Adrian Calin; Cinzia Sevignani; Calin Dan Dumitru; Terry Hyslop; Evan Noch; Sai Yendamuri; Masayoshi Shimizu; Sashi Rattan; Florencia Bullrich; Massimo Negrini; Carlo M Croce
Journal: Proc Natl Acad Sci U S A Date: 2004-02-18 Impact factor: 11.205

Targeted therapies through microRNAs: pulp or fiction?

1. MicroRNA miR-125a controls hematopoietic stem cell number.

2. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.

3. RAS is regulated by the let-7 microRNA family.

4. MicroRNA miR-125b causes leukemia.

5. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

6. c-Myc-regulated microRNAs modulate E2F1 expression.

7. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis.

8. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

9. A review on composite liposomal technologies for specialized drug delivery.

10. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality.

Review 1. Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential.

Review 2. Exploring circulating micro-RNA in the neoadjuvant treatment of breast cancer.