Literature DB >> 23555528

Pathogenesis of Vasculitis in env-pX Rats.

Akihiro Ishizu1, Takashi Yoshiki.   

Abstract

Transgenic rats carrying the env-pX gene of human T-cell leukemia virus type I (env-pX rats) develop necrotizing angiitis resembling human polyarteritis nodosa (PN). In the development of vasculitis in these rats, the thymus plays an important role. In this review, we provide an outline of the pathogenesis of vasculitis observed in env-pX rats, and discuss the developmental mechanism of human necrotizing angiitis such as PN with an unknown cause. (*English Translation of J Jpn Coll Angiol 2009; 49: 17-20.).

Entities:  

Keywords:  animal model; autoreactive T-cell; thymus; vasculitis

Year:  2012        PMID： 23555528      PMCID： PMC3595851          DOI： 10.3400/avd.ra.12.00063

Source DB:  PubMed          Journal:  Ann Vasc Dis        ISSN： 1881-641X


  11 in total

1.  Immunological hyperresponsiveness in HTLV-I LTR-env-pX transgenic rats: a prototype animal model for collagen vascular and HTLV-I-related inflammatory diseases.

Authors:  Y Nakamaru; A Ishizu; H Ikeda; T Sugaya; K Fugo; M Higuchi; H Yamazaki; T Yoshiki
Journal:  Pathobiology       Date:  2001       Impact factor: 4.342

2.  The structural proteins of murine leukemia virus and the pathogenesis of necrotizing arteritis and glomerulonephritis in SL/Ni mice.

Authors:  T Yoshiki; T Hayasaka; R Fukatsu; T Shirai; T Itoh; H Ikeda; M Katagiri
Journal:  J Immunol       Date:  1979-05       Impact factor: 5.422

3.  A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I.

Authors:  H Yamazaki; H Ikeda; A Ishizu; Y Nakamaru; T Sugaya; K Kikuchi; S Yamada; A Wakisaka; N Kasai; T Koike; M Hatanaka; T Yoshiki
Journal:  Int Immunol       Date:  1997-02       Impact factor: 4.823

4.  Articular tissues expressing the env-pX transgene are required for generation of arthritogenic T cells in human T cell leukemia virus type I transgenic rats.

Authors:  A Abe; A Ishizu; K Fugo; H Ikeda; T Yoshiki
Journal:  Clin Exp Rheumatol       Date:  2006 May-Jun       Impact factor: 4.473

5.  Aberrant gene expression by CD25+CD4+ immunoregulatory T cells in autoimmune-prone rats carrying the human T cell leukemia virus type-I gene.

Authors:  Hiroko Hayase; Akihiro Ishizu; Hitoshi Ikeda; Yukiko Miyatake; Tomohisa Baba; Masato Higuchi; Asami Abe; Utano Tomaru; Takashi Yoshiki
Journal:  Int Immunol       Date:  2005-05-20       Impact factor: 4.823

6.  Clonotypic analysis of T cells accumulating at arthritic lesions in HTLV-I env-pX transgenic rats.

Authors:  Toshiaki Sugaya; Akihiro Ishizu; Hitoshi Ikeda; Yuji Nakamaru; Kazunori Fugo; Masato Higuchi; Hidetoshi Yamazaki; Kohzoh Imai; Takashi Yoshiki
Journal:  Exp Mol Pathol       Date:  2002-02       Impact factor: 3.362

7.  Functional alteration of peripheral CD25(+)CD4(+)immunoregulatory T cells in a transgenic rat model of autoimmune diseases.

Authors:  Masato Higuchi; Akihiro Ishizu; Hitoshi Ikeda; Hiroko Hayase; Kazunori Fugo; Muneharu Tsuji; Asami Abe; Toshiaki Sugaya; Akira Suzuki; Toshiyuki Takahashi; Takao Koike; Takashi Yoshiki
Journal:  J Autoimmun       Date:  2003-02       Impact factor: 7.094

8.  Bone marrow cells carrying the env-pX transgene play a role in the severity but not prolongation of arthritis in human T-cell leukaemia virus type-I transgenic rats: a possible role of articular tissues carrying the transgene in the prolongation of arthritis.

Authors:  Asami Abe; Akihiro Ishizu; Hitoshi Ikeda; Hiroko Hayase; Takahiro Tsuji; Yukiko Miyatake; Muneharu Tsuji; Kazunori Fugo; Toshiaki Sugaya; Masato Higuchi; Takeo Matsuno; Takashi Yoshiki
Journal:  Int J Exp Pathol       Date:  2004-10       Impact factor: 1.925

9.  Promotion of early osteoclastogenesis and B lymphopoiesis in the bone marrow of transgenic rats with the env-pX gene of human T-cell lymphotropic virus type I.

Authors:  H Yamazaki; T Kunisada; A Ishizu; H Ikeda; I Miyoshi; T Sudo; S I Hayashi; T Yoshiki
Journal:  Oncogene       Date:  1998-12-10       Impact factor: 9.867

10.  The role of the thymus in development of necrotizing arteritis in transgenic rats carrying the env-pX gene of human T-cell leukemia virus type-I.

Authors:  Kazunori Fugo; Akihiro Ishizu; Hitoshi Ikeda; Hiroko Hayase; Toshiaki Sugaya; Masato Higuchi; Muneharu Tsuji; Asami Abe; Akira Suzuki; Masahiko Shibata; Toshiyuki Takahashi; Takashi Yoshiki
Journal:  Am J Pathol       Date:  2002-09       Impact factor: 4.307
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