Literature DB >> 23553840

Increased levels of gene therapy may not be beneficial in retinal disease.

Ellen Townes-Anderson.   

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Year:  2013        PMID： 23553840      PMCID： PMC3651456          DOI： 10.1073/pnas.1303746110

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  5 in total

1.  Histopathology and functional correlations in a patient with a mutation in RPE65, the gene for retinol isomerase.

Authors:  Vera L Bonilha; Mary E Rayborn; Yong Li; Gregory H Grossman; Eliot L Berson; Joe G Hollyfield
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-10-28       Impact factor: 4.799

2.  Mislocalized opsin and cAMP signaling: a mechanism for sprouting by rod cells in retinal degeneration.

Authors:  Jianfeng Wang; Nan Zhang; Annie Beuve; Ellen Townes-Anderson
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-09-19       Impact factor: 4.799

3.  Altered expression of retinal molecular markers in the canine RPE65 model of Leber congenital amaurosis.

Authors:  Maria Hernández; Susan E Pearce-Kelling; F David Rodriguez; Gustavo D Aguirre; Elena Vecino
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-07-29       Impact factor: 4.799

4.  Activation of mislocalized opsin kills rod cells: a novel mechanism for rod cell death in retinal disease.

Authors:  Peter D Alfinito; Ellen Townes-Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-09       Impact factor: 11.205

5.  Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement.

Authors:  Artur V Cideciyan; Samuel G Jacobson; William A Beltran; Alexander Sumaroka; Malgorzata Swider; Simone Iwabe; Alejandro J Roman; Melani B Olivares; Sharon B Schwartz; András M Komáromy; William W Hauswirth; Gustavo D Aguirre
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-22       Impact factor: 11.205
  5 in total
  2 in total

Review 1.  What Is Next for Retinal Gene Therapy?

Authors:  Luk H Vandenberghe
Journal:  Cold Spring Harb Perspect Med       Date:  2015-04-15       Impact factor: 6.915

2.  Reply to Townes-Anderson: RPE65 gene therapy does not alter the natural history of retinal degeneration.

Authors:  Artur V Cideciyan; Samuel G Jacobson; William A Beltran; William W Hauswirth; Gustavo D Aguirre
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-07       Impact factor: 11.205
  2 in total

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