OBJECTIVE: To assess the influence of infertility and fertility drugs on risk of ovarian tumors. DESIGN: Case-control study (Mayo Clinic Ovarian Cancer Study). SETTING: Ongoing academic study of ovarian cancer. PATIENT(S): A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders. RESULT(S): Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors. CONCLUSION(S): We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation. Published by Elsevier Inc.
OBJECTIVE: To assess the influence of infertility and fertility drugs on risk of ovarian tumors. DESIGN: Case-control study (Mayo Clinic Ovarian Cancer Study). SETTING: Ongoing academic study of ovarian cancer. PATIENT(S): A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders. RESULT(S): Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertilewomen who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertilewomen who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors. CONCLUSION(S): We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation. Published by Elsevier Inc.
Authors: Roberta B Ness; Daniel W Cramer; Marc T Goodman; Susanne Krûger Kjaer; Kathy Mallin; Berit Jul Mosgaard; David M Purdie; Harvey A Risch; Ronald Vergona; Anna H Wu Journal: Am J Epidemiol Date: 2002-02-01 Impact factor: 4.897
Authors: Michelle L Kurta; Kirsten B Moysich; Joel L Weissfeld; Ada O Youk; Clareann H Bunker; Robert P Edwards; Francesmary Modugno; Roberta B Ness; Brenda Diergaarde Journal: Cancer Epidemiol Biomarkers Prev Date: 2012-06-15 Impact factor: 4.254
Authors: Louise A Brinton; Emmet J Lamb; Kamran S Moghissi; Bert Scoccia; Michelle D Althuis; Jerome E Mabie; Carolyn L Westhoff Journal: Obstet Gynecol Date: 2004-06 Impact factor: 7.661
Authors: Louise A Brinton; Emmet J Lamb; Kamran S Moghissi; Bert Scoccia; Michelle D Althuis; Jerome E Mabie; Carolyn L Westhoff Journal: Fertil Steril Date: 2004-08 Impact factor: 7.329