J Brad Case 1 , Ross Palmer , Alex Valdes-Martinez , Erick L Egger , Kevin K Haussler Show Affiliations »
Abstract
OBJECTIVE: To report clinical findings and outcome in a dog with gastrocnemius tendon strain treated with autologous mesenchymal stem cells and a custom orthosis. STUDY DESIGN: Clinical report. ANIMAL: A 4-year-old spayed female Border Collie. METHODS: Bone-marrow derived, autologous mesenchymal stem cells were transplanted into the tendon core lesion. A custom, progressive, dynamic orthosis was fit to the tarsus. Serial orthopedic examinations and ultrasonography as well as long-term force-plate gait analysis were utilized for follow up. RESULTS: Lameness subjectively resolved and peak vertical force increased from 43% to 92% of the contralateral pelvic limb. Serial ultrasonographic examinations revealed improved but incomplete restoration of normal linear fiber pattern of the gastrocnemius tendon. CONCLUSIONS: Findings suggest that autologous mesenchymal stem cell transplantation with custom, progressive, dynamic orthosis may be a viable, minimally invasive technique for treatment of calcaneal tendon injuries in dogs. © Copyright 2013 by The American College of Veterinary Surgeons.
OBJECTIVE: To report clinical findings and outcome in a dog with gastrocnemius tendon strain treated with autologous mesenchymal stem cells and a custom orthosis. STUDY DESIGN: Clinical report. ANIMAL: A 4-year-old spayed female Border Collie. METHODS: Bone-marrow derived, autologous mesenchymal stem cells were transplanted into the tendon core lesion. A custom, progressive, dynamic orthosis was fit to the tarsus. Serial orthopedic examinations and ultrasonography as well as long-term force-plate gait analysis were utilized for follow up. RESULTS: Lameness subjectively resolved and peak vertical force increased from 43% to 92% of the contralateral pelvic limb. Serial ultrasonographic examinations revealed improved but incomplete restoration of normal linear fiber pattern of the gastrocnemius tendon. CONCLUSIONS: Findings suggest that autologous mesenchymal stem cell transplantation with custom, progressive, dynamic orthosis may be a viable, minimally invasive technique for treatment of calcaneal tendon injuries in dogs . © Copyright 2013 by The American College of Veterinary Surgeons.
Entities: Disease
Species
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Year: 2013
PMID： 23550707 DOI： 10.1111/j.1532-950X.2013.12007.x
Source DB: PubMed Journal: Vet Surg ISSN： 0161-3499 Impact factor: 1.495