Literature DB >> 23549990

A possible biomedical facility at the European Organization for Nuclear Research (CERN).

M Dosanjh1, B Jones, S Myers.   

Abstract

A well-attended meeting, called "Brainstorming discussion for a possible biomedical facility at CERN", was held by the European Organization for Nuclear Research (CERN) at the European Laboratory for Particle Physics on 25 June 2012. This was concerned with adapting an existing, but little used, 78-m circumference CERN synchrotron to deliver a wide range of ion species, preferably from protons to at least neon ions, with beam specifications that match existing clinical facilities. The potential extensive research portfolio discussed included beam ballistics in humanoid phantoms, advanced dosimetry, remote imaging techniques and technical developments in beam delivery, including gantry design. In addition, a modern laboratory for biomedical characterisation of these beams would allow important radiobiological studies, such as relative biological effectiveness, in a dedicated facility with standardisation of experimental conditions and biological end points. A control photon and electron beam would be required nearby for relative biological effectiveness comparisons. Research beam time availability would far exceed that at other facilities throughout the world. This would allow more rapid progress in several biomedical areas, such as in charged hadron therapy of cancer, radioisotope production and radioprotection. The ethos of CERN, in terms of open access, peer-reviewed projects and governance has been so successful for High Energy Physics that application of the same to biomedicine would attract high-quality research, with possible contributions from Europe and beyond, along with potential new funding streams.

Entities:  

Mesh:

Year:  2013        PMID: 23549990      PMCID: PMC3635800          DOI: 10.1259/bjr.20120660

Source DB:  PubMed          Journal:  Br J Radiol        ISSN: 0007-1285            Impact factor:   3.039


  5 in total

1.  ENLIGHT and other EU-funded projects in hadron therapy.

Authors:  M Dosanjh; B Jones; R Mayer; R Meyer
Journal:  Br J Radiol       Date:  2010-10       Impact factor: 3.039

2.  Fast neutron relative biological effects and implications for charged particle therapy.

Authors:  B Jones; T S A Underwood; A Carabe-Fernandez; C Timlin; R G Dale
Journal:  Br J Radiol       Date:  2011-12       Impact factor: 3.039

Review 3.  Proton vs carbon ion beams in the definitive radiation treatment of cancer patients.

Authors:  Herman Suit; Thomas DeLaney; Saveli Goldberg; Harald Paganetti; Ben Clasie; Leo Gerweck; Andrzej Niemierko; Eric Hall; Jacob Flanz; Josh Hallman; Alexei Trofimov
Journal:  Radiother Oncol       Date:  2010-02-23       Impact factor: 6.280

Review 4.  Charged particles in radiation oncology.

Authors:  Marco Durante; Jay S Loeffler
Journal:  Nat Rev Clin Oncol       Date:  2009-12-01       Impact factor: 66.675

Review 5.  Charged particles in radiotherapy: a 5-year update of a systematic review.

Authors:  Dirk De Ruysscher; M Mark Lodge; Bleddyn Jones; Michael Brada; Alastair Munro; Thomas Jefferson; Madelon Pijls-Johannesma
Journal:  Radiother Oncol       Date:  2012-02-10       Impact factor: 6.280

  5 in total
  7 in total

Review 1.  New challenges in high-energy particle radiobiology.

Authors:  M Durante
Journal:  Br J Radiol       Date:  2014-03       Impact factor: 3.039

2.  Why RBE must be a variable and not a constant in proton therapy.

Authors:  Bleddyn Jones
Journal:  Br J Radiol       Date:  2016-07       Impact factor: 3.039

3.  Feasibility study for a biomedical experimental facility based on LEIR at CERN.

Authors:  Daniel Abler; Adriano Garonna; Christian Carli; Manjit Dosanjh; Ken Peach
Journal:  J Radiat Res       Date:  2013-07       Impact factor: 2.724

4.  Towards Achieving the Full Clinical Potential of Proton Therapy by Inclusion of LET and RBE Models.

Authors:  Bleddyn Jones
Journal:  Cancers (Basel)       Date:  2015-03-17       Impact factor: 6.639

5.  Amino acid transport system - A substrate predicts the therapeutic effects of particle radiotherapy.

Authors:  Tomoya Uehara; Mariko Watanabe; Hiroyuki Suzuki; Yoshiya Furusawa; Yasushi Arano
Journal:  PLoS One       Date:  2017-02-28       Impact factor: 3.240

6.  A Simpler Energy Transfer Efficiency Model to Predict Relative Biological Effect for Protons and Heavier Ions.

Authors:  Bleddyn Jones
Journal:  Front Oncol       Date:  2015-08-11       Impact factor: 6.244

Review 7.  Medical Applications at CERN and the ENLIGHT Network.

Authors:  Manjit Dosanjh; Manuela Cirilli; Steve Myers; Sparsh Navin
Journal:  Front Oncol       Date:  2016-01-25       Impact factor: 6.244

  7 in total

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