José T Drost1, Yvonne T van der Schouw, Gerrie-Cor M Herber-Gast, Angela H E M Maas. 1. From the 1Department of Cardiology, Isala Klinieken, Zwolle, the Netherlands; 2Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; 3School of Population Health, University of Queensland, Brisbane, Australia; and 4Department of Cardiology, University Medical Center St Radboud, Nijmegen, the Netherlands.
Abstract
OBJECTIVE: Cardiovascular disease is the major cause of mortality in women worldwide. In recent years, several female-specific cardiovascular risk factors, such as hypertensive pregnancy diseases (HPDs) and vasomotor menopausal symptoms (VMS), have been identified. In this study, we evaluated the association between a history of HPD and the presence of VMS. METHODS: We consecutively included 853 women (mean age, 55.5 y) who visited the outpatient cardiovascular clinic for women in Kampen between 2003 and 2010. The visit included a questionnaire on history of HPD, demographic characteristics, and VMS; physical examination; and blood sampling. Logistic regression analysis was used to analyze the data. RESULTS: A history of HPD was reported by 274 women (32%), and VMS were reported by 83% of women with a history of HPD and by 75% of women without a history of HPD. In adjusted models, VMS were more often present (odds ratio [OR], 1.62; 95% CI, 1.00-2.63) and more frequently persisted for longer than 1 year (OR, 2.05; 95% CI, 1.08-3.89) among women with a history of HPD than among women with normotensive pregnancies. VMS were more often severe in women with a history of HPD, but this did not reach significance (adjusted OR, 1.28; 95% CI, 0.92-1.80). The frequency and intensity of VMS did not differ between both groups. CONCLUSIONS: In our "Kampen women cardiology clinic" cohort, women with a history of HPD report VMS during the menopausal transition significantly more often than women with normotensive pregnancies.
OBJECTIVE:Cardiovascular disease is the major cause of mortality in women worldwide. In recent years, several female-specific cardiovascular risk factors, such as hypertensive pregnancy diseases (HPDs) and vasomotor menopausal symptoms (VMS), have been identified. In this study, we evaluated the association between a history of HPD and the presence of VMS. METHODS: We consecutively included 853 women (mean age, 55.5 y) who visited the outpatient cardiovascular clinic for women in Kampen between 2003 and 2010. The visit included a questionnaire on history of HPD, demographic characteristics, and VMS; physical examination; and blood sampling. Logistic regression analysis was used to analyze the data. RESULTS: A history of HPD was reported by 274 women (32%), and VMS were reported by 83% of women with a history of HPD and by 75% of women without a history of HPD. In adjusted models, VMS were more often present (odds ratio [OR], 1.62; 95% CI, 1.00-2.63) and more frequently persisted for longer than 1 year (OR, 2.05; 95% CI, 1.08-3.89) among women with a history of HPD than among women with normotensive pregnancies. VMS were more often severe in women with a history of HPD, but this did not reach significance (adjusted OR, 1.28; 95% CI, 0.92-1.80). The frequency and intensity of VMS did not differ between both groups. CONCLUSIONS: In our "Kampen women cardiology clinic" cohort, women with a history of HPD report VMS during the menopausal transition significantly more often than women with normotensive pregnancies.
Authors: Angela H E M Maas; Giuseppe Rosano; Renata Cifkova; Alaide Chieffo; Dorenda van Dijken; Haitham Hamoda; Vijay Kunadian; Ellen Laan; Irene Lambrinoudaki; Kate Maclaran; Nick Panay; John C Stevenson; Mick van Trotsenburg; Peter Collins Journal: Eur Heart J Date: 2021-03-07 Impact factor: 29.983
Authors: Stephanie S Faubion; Amanda King; Andrea G Kattah; Carol L Kuhle; Richa Sood; Juliana M Kling; Kristin C Mara; Ekta Kapoor Journal: Menopause Date: 2020-08-17 Impact factor: 3.310