BACKGROUND: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. METHOD: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. RESULTS: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. CONCLUSIONS: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.
BACKGROUND: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. METHOD: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolarpatient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. RESULTS: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. CONCLUSIONS: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolarpatients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.
Authors: Ana Moreno-Alcázar; Joaquim Radua; Ramon Landín-Romero; Laura Blanco; Mercè Madre; Maria Reinares; Mercè Comes; Esther Jiménez; Jose Manuel Crespo; Eduard Vieta; Victor Pérez; Patricia Novo; Marta Doñate; Romina Cortizo; Alicia Valiente-Gómez; Walter Lupo; Peter J McKenna; Edith Pomarol-Clotet; Benedikt L Amann Journal: Trials Date: 2017-04-04 Impact factor: 2.279
Authors: Marco Pagani; Giorgio Di Lorenzo; Leonardo Monaco; Andrea Daverio; Ioannis Giannoudas; Patrizia La Porta; Anna R Verardo; Cinzia Niolu; Isabel Fernandez; Alberto Siracusano Journal: Front Psychol Date: 2015-10-27